Title:
環状スルホニウム塩の製造方法
Document Type and Number:
Japanese Patent JP5296555
Kind Code:
B2
Abstract:
Disclosed are: kotalanol which has an inhibitory activity on a glucosidase; a method for producing kotalanol or a cyclic sulfonium salt which is an analogue to kotalanol by an organic synthesis technique; a cyclic sulfonium salt produced by the method; a glucosidase inhibitor comprising the compound; an anti-diabetic agent or an anti-diabetic food comprising the glucosidase inhibitor. A sulfonium compound including kotalanol can be produced by coupling a thio-sugar synthesized from D-xylose (e.g., a compound having a cyclic structure composed of 4 carbon atoms and one sulfur atom, such as 1,4-dideoxy-1,4-epithio-D-arabinitol) with a heptitol cyclic sulfate ester having a protected hydroxyl group and synthesized from a pentose (D-xylose, D-ribose, D-arabinose, D-lyxose, L-xylose, L-ribose, L-arabinose or L-lyxose) to produce a cyclic sulfonium salt having a protected hydroxyl group, and then deprotecting the hydroxyl group.
Inventors:
Osamu Muraoka
Genzo Tanabe
Genzo Tanabe
Application Number:
JP2008552203A
Publication Date:
September 25, 2013
Filing Date:
January 04, 2008
Export Citation:
Assignee:
Takano Co., Ltd.
Kinki University
Kinki University
International Classes:
C07D333/46; A61K31/381; A61P3/10; A61P43/00; C07D327/10
Foreign References:
| WO2004113289A2 | 2004-12-29 |
Other References:
JPN6008019321; ＹＯＳＨＩＫＡＷＡ，Ｍ． ｅｔ ａｌ: 'Ｋｏｔａｌａｎｏｌ， ａ ｐｏｔｅｎｔ alpha-ｇｌｕｃｏｓｉｄａｓｅ ｉｎｈｉｂｉｔｏｒ ｗｉｔｈ ｔｈｉｏｓｕｇａｒ ｓｕｌｆｏｎｉｕｍ ｓｕｌｆａｔｅ ｓｔｒｕｃｔｕｒｅ， ｆｒｏｍ ａｎｔｉｄｉ' Ｃｈｅｍｉｃａｌ ＆ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｂｕｌｌｅｔｉｎ Ｖｏｌ．４６， Ｎｏ．８, 1998, ｐ．１３３９-１３４０
JPN6008019323; ＧＨＡＶＡＭＩ，Ａ． ｅｔ ａｌ: 'Ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｇｌｙｃｏｓｉｄａｓｅ ｉｎｈｉｂｉｔｏｒ： ｓｙｎｔｈｅｓｉｓ ｏｆ ｓａｌａｃｉｎｏｌ ａｎｄ ｉｔｓ ｓｔｅｒｅｏｉｓｏｍｅｒｓ' Ｊ Ｏｒｇ Ｃｈｅｍ Ｖｏｌ．６６， Ｎｏ．７, 2001, ｐ．２３１２-７
JPN6008019323; ＧＨＡＶＡＭＩ，Ａ． ｅｔ ａｌ: 'Ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｇｌｙｃｏｓｉｄａｓｅ ｉｎｈｉｂｉｔｏｒ： ｓｙｎｔｈｅｓｉｓ ｏｆ ｓａｌａｃｉｎｏｌ ａｎｄ ｉｔｓ ｓｔｅｒｅｏｉｓｏｍｅｒｓ' Ｊ Ｏｒｇ Ｃｈｅｍ Ｖｏｌ．６６， Ｎｏ．７, 2001, ｐ．２３１２-７
Attorney, Agent or Firm:
Kenichiro Matsuo