Title:
METHOD FOR PRODUCING DIBENZOTHIAZEPINE DERIVATIVE
Document Type and Number:
Japanese Patent JP2011126887
Kind Code:
A
Abstract:
To provide a new method for producing a dibenzothiazepine derivative useful as a starting material for producing 11-[4-(2-(2-hydroxyethoxy)ethyl)]-1-piperazinylbenzothiazepine derivative useful as an antipsychotic agent.
This compound expressed by formula (5) [wherein, each of symbols is specifically defined] is produced by reacting a specific nitrobenzene derivative with a specific thiosalicylic acid derivative, thereafter reducing the obtained 2-nitro-2'-carboxy-diphenyl sulfide derivative, and further performing the dehydrating condensation of the obtained 2-amino-2'-carboxy-diphenyl sulfide derivative.
Inventors:
HARADA KATSUMASA
NISHINO SHIGEYOSHI
YOSHII KIYOTAKA
NISHINO SHIGEYOSHI
YOSHII KIYOTAKA
Application Number:
JP2011002831A
Publication Date:
June 30, 2011
Filing Date:
January 11, 2011
Export Citation:
Assignee:
UBE INDUSTRIES
ASTRAZENECA UK LTD
ASTRAZENECA UK LTD
International Classes:
C07D281/16; C07C319/14; C07C323/62; C07B61/00
Domestic Patent References:
| JPS60202879A | 1985-10-14 | |||
| JP3865096B2 | 2007-01-10 | |||
| JP4688383B2 | 2011-05-25 |
Other References:
JPN4004001999; Ｏ．Ｆ．Ｂｅｎｎｅｔｔ ｅｔ ａｌ．: Ｊｏｕｒｎａｌ ｏｆ Ｈｅｔｅｒｏｃｙｃｌｉｃ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１２，Ｎｏ．６, 1975, １２１１-１２１３
JPN6009034840; ＳＨＯＷＡＬＴＥＲ，Ｈ．Ｄ． ｅｔ ａｌ: 'Ｂｅｎｚｏｔｈｉｏｐｙｒａｎｏｉｎｄａｚｏｌｅｓ， ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｃｈｒｏｍｏｐｈｏｒｅ ｍｏｄｉｆｉｅｄ ａｎｔｈｒａｃｅｎｅｄｉｏｎｅ ａｎｔｉｃａｎｃｅｒ ａｇｅｎｔｓ． Ｓｙｎ' Ｊ Ｍｅｄ Ｃｈｅｍ Ｖｏｌ．３１， Ｎｏ．８, 1988, ｐ．１５２７-１５３９
JPN6010002326; Ｊｏｓｈｉ， Ｂ． Ｃ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｓｔｒｕｃｔｕｒａｌ ｓｔｕｄｉｅｓ ｏｆ ８-ａｍｉｎｏ-１０，１１-ｄｉｈｙｄｒｏ-５Ｈ-ｄｉｂｅｎｚｏ［ｂ，ｅ］［１，４］ｔｈｉａｚｅｐｉｎｅ-１１-ｏｎｅ' Ｃｈｅｍｉｓｔｒｙ ＆ Ｉｎｄｕｓｔｒｙ （Ｌｏｎｄｏｎ， Ｕｎｉｔｅｄ Ｋｉｎｇｄｏｍ） Ｖｏｌ．１６， Ｎｏ．２４, 1985, ｐ．８２５-６
JPN6010002329; Ｋｕｌｋａｒｎｉ， Ｎ． Ｎ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｔｉｃ ｓｔｕｄｉｅｓ ｏｎ ｍｅｄｉｕｍ ａｎｄ ｌａｒｇｅ ｒｉｎｇ ｅｓｔｅｒｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．４４， Ｎｏ．１６, 1988, ｐ．５１４５-９
JPN6010002333; Ｂｒａｎｎｉｇａｎ， Ｌ． Ｈ． ｅｔ ａｌ．: 'Ｂｉｏｌｏｇｉｃａｌｌｙ ｏｒｉｅｎｔｅｄ ｏｒｇａｎｉｃ ｓｕｌｆｕｒ ｃｈｅｍｉｓｔｒｙ． １４． Ａｎｔｉｉｎｆｌａｍｍａｔｏｒｙ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｓｏｍｅ ａｒｙｌ ｓｕｌｆｉｄｅ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１９， Ｎｏ．６, 1976, ｐ．７９８-８０２
JPN6010002336; 日本化学会編: 実験化学講座第４版 ２０ 有機合成ＩＩ, 1991, ｐ．２７９-８１, 丸善
JPN6009034840; ＳＨＯＷＡＬＴＥＲ，Ｈ．Ｄ． ｅｔ ａｌ: 'Ｂｅｎｚｏｔｈｉｏｐｙｒａｎｏｉｎｄａｚｏｌｅｓ， ａ ｎｅｗ ｃｌａｓｓ ｏｆ ｃｈｒｏｍｏｐｈｏｒｅ ｍｏｄｉｆｉｅｄ ａｎｔｈｒａｃｅｎｅｄｉｏｎｅ ａｎｔｉｃａｎｃｅｒ ａｇｅｎｔｓ． Ｓｙｎ' Ｊ Ｍｅｄ Ｃｈｅｍ Ｖｏｌ．３１， Ｎｏ．８, 1988, ｐ．１５２７-１５３９
JPN6010002326; Ｊｏｓｈｉ， Ｂ． Ｃ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｓｔｒｕｃｔｕｒａｌ ｓｔｕｄｉｅｓ ｏｆ ８-ａｍｉｎｏ-１０，１１-ｄｉｈｙｄｒｏ-５Ｈ-ｄｉｂｅｎｚｏ［ｂ，ｅ］［１，４］ｔｈｉａｚｅｐｉｎｅ-１１-ｏｎｅ' Ｃｈｅｍｉｓｔｒｙ ＆ Ｉｎｄｕｓｔｒｙ （Ｌｏｎｄｏｎ， Ｕｎｉｔｅｄ Ｋｉｎｇｄｏｍ） Ｖｏｌ．１６， Ｎｏ．２４, 1985, ｐ．８２５-６
JPN6010002329; Ｋｕｌｋａｒｎｉ， Ｎ． Ｎ． ｅｔ ａｌ．: 'Ｓｙｎｔｈｅｔｉｃ ｓｔｕｄｉｅｓ ｏｎ ｍｅｄｉｕｍ ａｎｄ ｌａｒｇｅ ｒｉｎｇ ｅｓｔｅｒｓ' Ｔｅｔｒａｈｅｄｒｏｎ Ｖｏｌ．４４， Ｎｏ．１６, 1988, ｐ．５１４５-９
JPN6010002333; Ｂｒａｎｎｉｇａｎ， Ｌ． Ｈ． ｅｔ ａｌ．: 'Ｂｉｏｌｏｇｉｃａｌｌｙ ｏｒｉｅｎｔｅｄ ｏｒｇａｎｉｃ ｓｕｌｆｕｒ ｃｈｅｍｉｓｔｒｙ． １４． Ａｎｔｉｉｎｆｌａｍｍａｔｏｒｙ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｓｏｍｅ ａｒｙｌ ｓｕｌｆｉｄｅ' Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１９， Ｎｏ．６, 1976, ｐ．７９８-８０２
JPN6010002336; 日本化学会編: 実験化学講座第４版 ２０ 有機合成ＩＩ, 1991, ｐ．２７９-８１, 丸善
Attorney, Agent or Firm:
Yanagawa Yasuo
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