Title:
ジエチレントリアミン五酢酸誘導体の製造方法およびジエチレントリアミン五酢酸誘導体
Document Type and Number:
Japanese Patent JP5725561
Kind Code:
B2
Abstract:
The objective of the present invention is to provide a process for simple and efficient preparation of an intermediate compound to synthesize a gadolinium complex having a substituent for improving a retention property in blood time and specificity to an intended organ. The objective of the present invention is also to provide an intermediate compound produced by the said production process. The process for preparation of the diethylenetriaminepentaacetic acid derivative (I):
wherein R 1 to R 5 are independently C 1-6 alkyl groups;
comprising the steps of:
reacting a diethylenetriaminepentaacetic acid pentaester with a halogenated ally compound in an aprotic solvent;
removing the excess halogenated ally compound (III); and
reacting a reaction product of the diethylenetriaminepentaacetic acid pentaester and the halogenated ally compound with a base in a solvent.
Inventors:
Nao Nemoto
Satoshi Kawamura
Kenji Yatsuka
Kamiya Masaki
Satoshi Kawamura
Kenji Yatsuka
Kamiya Masaki
Application Number:
JP2011536083A
Publication Date:
May 27, 2015
Filing Date:
September 22, 2010
Export Citation:
Assignee:
Tokushima University
International Classes:
C07C227/16; C07C229/30; C07C229/34; C07C233/49; C07C239/16; C07C271/22; C07C271/66; C07D207/452
Domestic Patent References:
| JPH11501012A | 1999-01-26 | |||
| JPH0931037A | 1997-02-04 | |||
| JPH11501012A | 1999-01-26 | |||
| JPH0931037A | 1997-02-04 |
Foreign References:
| CH283612A | 1952-06-15 | |||
| FR1392029A | 1965-03-12 | |||
| FR2166276A1 | 1973-08-17 | |||
| GB533718A | 1941-02-19 | |||
| US2151733A | 1939-03-28 |
Attorney, Agent or Firm:
Kyuichi Ueki
Hisahiko Ueki
Tadashi Sugakawa
Hiroaki Ito
Hisahiko Ueki
Tadashi Sugakawa
Hiroaki Ito