Title:
ジオキソペニシラン酸誘導体の製造方法
Document Type and Number:
Japanese Patent JP4050856
Kind Code:
B2
Abstract:
Procedure for the preparation of dioxopenicillanic acid derivatives and its salts pharmaceutically acceptable with general formula I, where, R is hydrogen, alkyl group containing 1 to 5 Carbon atoms or a residue of type -CH2R ', where R ' is hydrogen, halogen or a p-toluensulfonyl group. These are prepared by treatment of the compounds of general formula II, where R is as previously defined and X may be hydrogen or bromine, with a metallic reagent constituted by a mixture or alloy of copper and/or cobalt and/or manganese with iron and/or nickel in an aqueous/organic medium. These compounds are useful as inhibitors of beta-lactamase.
Inventors:
Juan Pedro de la Fuente Morata
Application Number:
JP2000057439A
Publication Date:
February 20, 2008
Filing Date:
March 02, 2000
Export Citation:
Assignee:
Alex-Giocell Katathasi, Fayresthesi Ace Tanner Chadaw Korla Tort Ferrere Segou Tarsagagg
International Classes:
C07D499/04; C07D277/60; C07D499/00; C07D499/86; A61P31/00
Domestic Patent References:
| JP64066189A | ||||
| JP55120588A |
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Takashi Nakata
Shosuke Imai
Tadashi Masui
Tadahiko Kurita
Yasushi Kobayashi
Takashi Nakata