Title:
ドパミン神経細胞の製造方法
Document Type and Number:
Japanese Patent JP6419073
Kind Code:
B2
Abstract:
The present invention provides a method of more efficiently producing a high-quality dopaminergic neuron from neural progenitor cells, specifically, a production method of a dopaminergic neuron including a step of culturing neural progenitor cells in a medium containing (i) a cAMP analogue and (ii) a MEK inhibitor. Moreover, the present invention also provides a medicament containing a dopaminergic neuron obtained by the method, and a reagent and a kit to be used for the method.
Inventors:
Masanobu Shoji
Application Number:
JP2015530994A
Publication Date:
November 07, 2018
Filing Date:
August 06, 2014
Export Citation:
Assignee:
Takeda GmbH
International Classes:
C12N5/0793; C12N5/0797
Foreign References:
| WO2004081172A2 |
Other References:
J. Cell. Biochem.,2010年 2月 1日,Vol.109, No.2,p.292-301
Nature,2011年11月 6日,Vol.480, No.7378,p.547-551
Development,2011年10月,Vol.138, No.20,p.4363-4374
Stem Cells,2012年11月,Vol.30, No.11,p.2400-2411
J. Neurochem.,2007年11月,Vol.103, No.3,p.962-971
Biochem. Biophys. Res. Commun.,2010年 4月 9日,Vol.394, No.3,p.639-645
Nature,2011年11月 6日,Vol.480, No.7378,p.547-551
Development,2011年10月,Vol.138, No.20,p.4363-4374
Stem Cells,2012年11月,Vol.30, No.11,p.2400-2411
J. Neurochem.,2007年11月,Vol.103, No.3,p.962-971
Biochem. Biophys. Res. Commun.,2010年 4月 9日,Vol.394, No.3,p.639-645
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Murata Miyuki
Junzo Koike
Hirofumi Toma
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