Title:
METHOD FOR PRODUCING EXTRACELLULAR VESICLES CONTAINING BIOACTIVE SUBSTANCE
Document Type and Number:
Japanese Patent JP2023167506
Kind Code:
A
Abstract:
To provide a method for efficiently producing extracellular vesicles containing a bioactive substance such as sonic hedgehog (Shh).SOLUTION: In the present invention, a solution to the problem is a method that is for producing extracellular vesicles and that comprises acquiring extracellular vesicles secreted from cells having undergone a treatment for inactivating Rab GTPase such as Rab18. Preferably, the cells are cells that express Shh. In the present invention, another solution to the problem is an extracellular vesicle that contains Shh and that has a particle size of 800 nm or more and/or a volume of 109 nm3 or more.SELECTED DRAWING: None
Inventors:
TANAKA YOSUKE
WANG SHUO
WANG SHUO
Application Number:
JP2022078750A
Publication Date:
November 24, 2023
Filing Date:
May 12, 2022
Export Citation:
Assignee:
UNIV TOKYO
International Classes:
A61K35/12; C12N5/0775; A61K35/28; A61P9/00; A61P9/10; C12Q1/02; G01N33/50
Attorney, Agent or Firm:
Koji Okuhara