Title:
METHOD FOR PRODUCING FESOTERODINE
Document Type and Number:
Japanese Patent JP2011102295
Kind Code:
A
Abstract:
To provide a method for efficiently synthesizing (R)-2-(3-diisopropylamino-1-phenylpropyl)-4-(hydroxymethyl)-phenol isobutyrate (Fesoterodine) and its (S)-enantiomer fesoterodine, by which the synthesis of the Fesoterodine and its (S)-enantiomer fesoterodine can be attained in high purity and in an industrial scale from low cost starting materials.
The method for producing the Fesoterodine and its (S)-enantiomer includes resolving a racemic compound represented by formula (II) (wherein Ra is 1C to 6C alkyl) by the formation of a diastereomer salt of the racemic compound with an optically active organic acid, reducing the ester portion, and then isobutylating the phenolic hydroxyl group.
Inventors:
MANTEGAZZA SIMONE
ALLEGRINI PIETRO
ATTOLINO EMANUELE
ALLEGRINI PIETRO
ATTOLINO EMANUELE
Application Number:
JP2010241700A
Publication Date:
May 26, 2011
Filing Date:
October 28, 2010
Export Citation:
Assignee:
DIPHARMA FRANCIS SRL
International Classes:
C07C227/34; C07C213/00; C07C215/54; C07C219/28; C07C227/16; C07C229/34; C07B57/00; C07B61/00
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito