Title:
臭化水素酸ガランタミンの製造方法
Document Type and Number:
Japanese Patent JP5166878
Kind Code:
B2
Abstract:
A process for the purification of galanthamine (I) comprising precipitation of galanthamine hydrobromide from a mixture of alkaloids obtained from a plant of the Amaryllidaceae family containing galanthamine, treatment of the hydrobromide with alkali, extraction and crystallization of galanthamine with a solvent of general formula (II), in which R1 is hydrogen or methyl and R2 is selected from n-butyl, isobutyl, sec-butyl and t-butyl. The resulting pure galanthamine can be conveniently used for the preparation of galanthamine hydrobromide.
Inventors:
Gabbetta, Bruno
Mercari, Enrico
Mercari, Enrico
Application Number:
JP2007545863A
Publication Date:
March 21, 2013
Filing Date:
November 23, 2005
Export Citation:
Assignee:
Indena Sochieta Pell Ationi
International Classes:
C07D491/06
Foreign References:
| GB938767B | ||||
| WO1996029332A1 |
Attorney, Agent or Firm:
Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito
Koshiro Tsukuda
Fusayuki Saito