Title:
高純度2-メトキシエストラジオールの生成方法
Document Type and Number:
Japanese Patent JP5317381
Kind Code:
B2
Abstract:
2-methoxyestradiol having greater than 98% purity is obtained by synthetic or purification methods. This highly pure 2-methoxy estradiol, lacking estrogenic components, is particularly suitable for clinical use in humans. The purification methods of the invention involve the use of liquid-solid chromatography (LSC) to separate 2-ME2 from other compounds. The chromatographic media is preferably silica. The solvent system comprises a non-polar solvent, such as chloroform, and a polar solvent, such as methanol.
Inventors:
Agoston, Gregory E.
Treston, Anthony M.
Shah, Jam Shed H.
Treston, Anthony M.
Shah, Jam Shed H.
Application Number:
JP2001518734A
Publication Date:
October 16, 2013
Filing Date:
August 23, 2000
Export Citation:
Assignee:
Entremed Incorporated
International Classes:
A61K31/565; C07J1/00; A61P9/00; A61P9/10; A61P15/00; A61P15/08; A61P17/02; A61P19/02; A61P27/02; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07B61/00
Other References:
Synthesis,1977年,No.3,p.168-169
Steroids,1986年,Vol.47, No.1,p.63-66
Chem. Pharm. Bull.,1983年,Vol.31, No.9,p.3309-3314
J. Med. Chem.,1995年,Vol.38, No.12,p.2041-2049
Synthetic Communications,1998年,Vol.28, No.23,p.4431-4437
Steroids,1986年,Vol.47, No.1,p.63-66
Chem. Pharm. Bull.,1983年,Vol.31, No.9,p.3309-3314
J. Med. Chem.,1995年,Vol.38, No.12,p.2041-2049
Synthetic Communications,1998年,Vol.28, No.23,p.4431-4437
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi
Shinichi Sanuki
Takeshi Niwa
Shinichi Sanuki
Takeshi Niwa
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