To provide a method for producing isepamicin which is a semi-synthetic antibiotic substance belonging to an aminoglycoside group, by using simple synthetic procedures.
This method for producing the isepamicin is provided by performing an interaction of zinc pivalate with gentamicin B, and a selective blocking of 3, 6'-amino groups of the gentamicin B performed through an interaction of benzyloxycarbonyloxysuccinimide with the gentamicin B in dimethyl sulfoxide solvent in the presence of zinc pivalate at a room temperature under continuous agitation, then adding ammonia water, diluting the obtained mixture with water, adjusting pH at 7.5 by using phosphate buffer of 2M concentration and purifying the obtained 3, 6'-di-N-benzyloxycarbonygentamicin B with a weakly cationic ion exchange resin.
PENEV PAVEL NENOV
DONCHEV IVAN N
ANGELOVA NELY TZONEVA
GROZDANOV GEORGY ASENOV
IVANOVA KARMELINA P
MINCHEVA DESISLAVA TODOROVA
AGAPOVA KRASIMIRA N
IVANOVA MARIANA KRISTOPHER
PETKOV NEDELCHO GENOV
IVANOV TARPANOV VELICHKO
ARTIN KRILORYAN DIKRAN
PARCHEV STOJAN PARCHEV
MECKAROVA-TODOROVA PEPA DIMITR
DOKTOROV CONSTANTIN NIKOLOV
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