Title:
カケロマイシンおよびその誘導体の製造方法
Document Type and Number:
Japanese Patent JP6610905
Kind Code:
B2
Abstract:
Provided is a production method of kakeromycin and a derivative thereof showing an antifungal activity and cytotoxicity and expected as a new antifungal agent or anticancer agent, by chemical synthesis. A production method of a compound represented by the formula (1):
wherein R is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group; and n is 0 or 1, or a salt thereof, including a step of subjecting a compound represented by the formula (2):
wherein R and n are as defined above, or a salt thereof, to an oxidation reaction.
Inventors:
Akihiko Ishikawa
Morita Iwami
Morita Iwami
Application Number:
JP2017502519A
Publication Date:
November 27, 2019
Filing Date:
February 26, 2016
Export Citation:
Assignee:
OP Bio Factory Co., Ltd.
Seed Search Laboratory Co., Ltd.
Seed Search Laboratory Co., Ltd.
International Classes:
C07D498/04; C07C221/00; C07C225/06; C07C225/10; C07C225/16; C07C269/06; C07C271/18; C07D211/46; C07D211/74; C07D261/04
Foreign References:
| WO2015030197A1 |
Other References:
MATSUMOTO Y et al., A novel antifungal agent discovered from Streptomyces sp. in sea sand, Poster pr
平成25年度 戦略的基盤技術高度化支援事業 「新たな分離源処理法及び発酵培養法の開発による海洋性微生物,2014年 3月,Retrieved from the Internet:
平成25年度 戦略的基盤技術高度化支援事業 「新たな分離源処理法及び発酵培養法の開発による海洋性微生物,2014年 3月,Retrieved from the Internet:
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Junzo Koike
Hirofumi Toma
Atsuko Akai
Tomiya Tozaki