To provide a method comprising producing 5-(thiazolylmethylene) hydantoin which is a new compound obtained from thiazole-aldehyde and hydantoin, producing 2-hydroxy-3-thiazolylacrylic acid and/or a salt thereof, and further producing L-thyazolylalanine by using the compound as a raw material.
This method for producing the L-thyazolylalanine comprises reacting the thiazole-aldehyde with the hydantoin in the presence of 2- aminoethanol to provide the 5-(thiazolylmethylene)hydantoin, hydrolyzing the produced 5-(thiazolylmethylene)hydantoin in the presence of a base to provide the 2-hydroxy-3-thiazolylacrylic acid and/or the salt thereof, and subjecting the obtained 2-hydroxy-3-thiazolylacrylic acid and/or the salt thereof to an amino group-transfer reaction from a natural amino acid by using an enzyme.
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TOKUHISA KENJI
KAKIYA HITOSHI
HANZAWA SATOSHI
OE MASATAKE
