Title:
光学活性2-ヒドロキシ酪酸エステルの製造法
Document Type and Number:
Japanese Patent JP5094392
Kind Code:
B2
Abstract:
To provide a process for producing an optically active 2-hydroxybutyric ester at high yield and high optical purity. The process for producing an optically active 2-hydroxybutyric ester (1), characterized in that the process includes reacting an optically active 2,3-epoxypropionic ester (2) with a methyl Grignard reagent CH 3 MgX (wherein X represents a halogen atom) in the presence of a copper catalyst in an amount of 0.05 to 0.5 mol with respect to 1 mol of (2) through the following scheme:
(wherein R represents a C1 to C6 alkyl group or a C7 or C8 aralkyl group; X represents a halogen atom; and * represents S- or R-absolute configuration).
Inventors:
Minoru Koura
Yuko Yamazaki
Shibuya Kimiyuki
Yuko Yamazaki
Shibuya Kimiyuki
Application Number:
JP2007526891A
Publication Date:
December 12, 2012
Filing Date:
July 27, 2006
Export Citation:
Assignee:
Kowa Co., Ltd.
International Classes:
C07C67/343; C07C69/675; C07B49/00; C07B53/00; C07B61/00
Domestic Patent References:
| JPS62212329A | 1987-09-18 | |||
| JPH0436195A | 1992-02-06 |
Attorney, Agent or Firm:
Alga Patent Office, a patent business corporation
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto
Miyuki Ariga
Toshio Takano
Toshio Nakajima
Masaki Murata
Hiroto Yamamoto