Title:
光学活性ベンジルアミン誘導体の製造方法
Document Type and Number:
Japanese Patent JP4834333
Kind Code:
B2
Abstract:
A benzylamine derivative has a structure represented by the following formula (1): In a method for optical resolution of the benzylamine derivative, optically active mandelic acid is used as an optical resolving agent. In an optical resolution step in a production method of the optically active benzylamine derivative, an optically active (S)-benzylamine derivative represented by the formula (3) is precipitated as (S)-mandelic acid salt from a solution containing the benzylamine derivative and (S)-mandelic acid: wherein Ar represents an aryl group that has 6 to 15 carbon atoms and may have a substituent, and *1 represents an asymmetric carbon atom.
Inventors:
Sugiyama Teruaki
Fujishima Akinori
Atsushi Umeya
Matsunaga Nobutaka
Yoshiyuki Omori
Norihiko Seko
Fujishima Akinori
Atsushi Umeya
Matsunaga Nobutaka
Yoshiyuki Omori
Norihiko Seko
Application Number:
JP2005187347A
Publication Date:
December 14, 2011
Filing Date:
June 27, 2005
Export Citation:
Assignee:
Alps Pharmaceutical Industry Co., Ltd.
International Classes:
C07C225/16; C07B57/00
Domestic Patent References:
| JP2002535298A | ||||
| JP2003507357A | ||||
| JP8208572A |
Foreign References:
| WO2003104186A1 | ||||
| WO1994001392A1 |
Other References:
Hideo TAKEDA, et al.,「EFFICIENT ASYMMETRIC HYDROGENATION OF α-AMINOACETOPHENONE DERIVATIVES LEADING TO PRACTICAL SYNTHESIS OF (S)-(-)-LEVAMISOLE」,Tetrahedron Letters,1989年,vol.30,no.3,p.363-366,Table 1
DURGESH Nadkarni, et al.,「Diastereoselectivity in the Reduction of α-Oxy- and α-Amino-Substituted Acyclic Ketones by Polymethylhydrosiloxane」,Journal of Organic Chemistry,2003年,vol.68, no.2,p.594-596,TABLE 1., SCHEME 2
DURGESH Nadkarni, et al.,「Diastereoselectivity in the Reduction of α-Oxy- and α-Amino-Substituted Acyclic Ketones by Polymethylhydrosiloxane」,Journal of Organic Chemistry,2003年,vol.68, no.2,p.594-596,TABLE 1., SCHEME 2
Attorney, Agent or Firm:
Hironobu Onda
Makoto Onda
Makoto Onda