Title:
光学活性ヒドラジン化合物および光学活性アミン化合物の製造方法
Document Type and Number:
Japanese Patent JP4793976
Kind Code:
B2
Abstract:
The present invention relates to a production method of optically active hydrazine compound (IV), which includes reacting azo compound (II) with compound (III) in the presence of optically active compound (I). The present invention also relates to a production method of optically active amine compound (V), which includes producing optically active hydrazine compound (IV) by the above-mentioned method, reacting the optically active hydrazine compound (IV) with a base or an acid to eliminate a protecting group represented by PG, and then subjecting the resulting compound to catalytic reduction or reacting the resulting compound with a zinc powder to reduce a nitrogen-nitrogen bond. wherein X is S or O; C*, C** and C*** are asymmetric carbons, R1 and R2 are lower alkyl groups etc., R4 and R5 may in combination form cyclohexane etc., R3 is aryl group optionally having substituent(s) etc., R6 and R7 are hydrogen atoms etc., R8 is aryl group optionally having substituent(s) etc., R9 and R10 are electron withdrawing groups, and PG is a protecting group.
Inventors:
Takemoto Koji
Kazuo Murakami
Kazuo Murakami
Application Number:
JP2005054799A
Publication Date:
October 12, 2011
Filing Date:
February 28, 2005
Export Citation:
Assignee:
Kyoto University
Sumitomo Chemical Co., Ltd.
Sumitomo Chemical Co., Ltd.
International Classes:
C07C221/00; C07C225/20; C07C227/06; C07C229/48; C07C229/50; C07C253/30; C07C255/42; C07C281/02; C07B51/00; C07B53/00; C07B61/00
Foreign References:
| WO2005000803A1 | ||||
| WO2005058805A1 |
Other References:
Journal of the American Chemical Society,2004年,Vol.126,p.8120-8121
Angewandte Chemie International Edition,2002年,Vol.41,p.1790-1793
Angewandte Chemie International Edition,2002年,Vol.41,p.1790-1793
Attorney, Agent or Firm:
Takashima Ichi