Title:
METHOD FOR PRODUCING OPTICALLY ACTIVE SECONDARY ALCOHOL COMPOUND
Document Type and Number:
Japanese Patent JP2005029503
Kind Code:
A
Abstract:
To provide a method for producing an optically active high-purity secondary alcohol compound in high purity industrially useful as an intermediate for a medicine, an agrochemical or a perfume by asymmetrically reducing a ketone compound by using inexpensive and readily handleable trichlorosilane as a reducing agent.
An asymmetric ketone compound such as acetophenone, etc., is reduced with trichlorosilane in the presence of an optically active N-picolinoylpyrrolidine derivative represented by formula (1) (R is a 2-5C alkoxycarbonyl group, a 2-5C alkoxymethyl group or a hydroxymethyl group) such as picolinoyl-(S)-2-methoxycarbonylpyrrolidine.
Inventors:
MATSUMURA ISAHIRO
ONOMURA OSAMU
IWASAKI FUMIAKI
ONOMURA OSAMU
IWASAKI FUMIAKI
Application Number:
JP2003196196A
Publication Date:
February 03, 2005
Filing Date:
July 14, 2003
Export Citation:
Assignee:
TOKUYAMA CORP
International Classes:
C07C29/143; C07B53/00; C07B61/00; C07C33/22; (IPC1-7): C07C29/143; C07B53/00; C07C33/22