To provide a phosphatide complex containing phosphatide or a salt thereof, phosphatidic acid and phosphatidyl serine, as a therapeutic agent for disorders caused by stress.

The production method includes (a) a step using raw material lecithin as a substrate and a water-insoluble surfactant matrix material having a particle size of 0.01 mm or more, and (b) a step for enzymatic treatment of a mixture of the water insoluble surfactant-matrix material with the raw material lecithin, and phospholipase D, racemic acid or isometrically pure amino acid, or amine and a salt, in a pH-buffer aqueous solution.