Title:
ビス(メタ)アクリルアミド糖を基材としたポリマー担体材料の製造方法
Document Type and Number:
Japanese Patent JP2008504410
Kind Code:
A
Abstract:
The invention relates to methods for the production of polymer carrier materials for solid phase synthesis, particularly for peptide synthesis. (Meth)acrylamide derivatives based on carbon hydrates, which can also contain other protective groups, are polymerized by means of suspension polymerization in an aqueous phase, optionally with the addition of pore-forming additives, and subsequently the protective groups are fully or partially cleaved. It is thus possible to obtain polymer carriers whose morphology (particle size, porosity), degree of cross-linking and swelling capability in aqueous and organic media can be adjusted in a targeted manner and whose reactive groups offer multiple opportunities for the immobilization of anchor groups and protective groups. The hydroxyl groups of the polymer carrier can be activated according to usual methods of solid phase synthesis.
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Inventors:
Beldians, Thomas
Gruber, Heinrich
Kunaus, Simone
Postalco, Alexandre
Gruber, Heinrich
Kunaus, Simone
Postalco, Alexandre
Application Number:
JP2007518406A
Publication Date:
February 14, 2008
Filing Date:
June 24, 2005
Export Citation:
Assignee:
Tehinische Universitate Vienna
International Classes:
C08F20/58; B01D15/08; B01J20/26; B01J20/285; C07K1/04; C08F220/58; B01D15/38
Attorney, Agent or Firm:
Takashima Ichi