Title:
多価不飽和ケトン化合物の製造方法
Document Type and Number:
Japanese Patent JP6563921
Kind Code:
B2
Abstract:
The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-acceptable polyunsaturated ester or thioester compound directly, which can ultimately be converted to the advantageous ketone compounds, in which unwanted oxidation and cis/trans isomerization are substantially reduced or eliminated using particular Mitsonobu chemistry.
Inventors:
Sandberg, Marcel
Aukurst, Ingel-Reidan
Aukurst, Ingel-Reidan
Application Number:
JP2016528529A
Publication Date:
August 21, 2019
Filing Date:
July 23, 2014
Export Citation:
Assignee:
Avexin AS
International Classes:
C07C327/22; C07C29/14; C07C33/02; C07C319/02; C07C319/14; C07C321/08; C07C321/18
Domestic Patent References:
| JP2011528350A | ||||
| JP3173841A | ||||
| JP2001505869A | ||||
| JP2010202608A | ||||
| JP6032773A | ||||
| JP2006509800A |
Other References:
HOLMEIDE A K,SYNTHESES OF SOME POLYUNSATURATED TRIFLUOROMETHYL KETONES AS POTENTIAL PHOSPHOLIPASE A2 INHIBITORS,JOURNAL OF THE CHEMICAL SOCIETY , PERKIN TRANSACTIONS 1,英国,ROYAL SOCIETY OF CHEMISTRY,2000年 1月 1日,No.14,PAGE(S):2271 - 2276,URL,http://dx.doi.org/10.1039/b001944p
Attorney, Agent or Firm:
Patent business corporation Ikeuchi and Partners