Title:
METHOD FOR PRODUCING PROSTAGLANDIN AND ANALOGUE THEREOF
Document Type and Number:
Japanese Patent JP2010053149
Kind Code:
A
Abstract:
To provide a purification method for a latanoprost and a high-purity latanoprost.
The method for purifying the latanoprost is conducted by HPLC characterized by use of a mixture containing one ore more hydrocarbons, one or more alcohols, and arbitrarily an acetonitrile as an eluent. According to the method, a latanoprost which does not substantially contain a 15 (S)-cis isomer, a 15 (S)-trans isomer or a 15 (R)-trans isomer, preferably a latanoprost with 98% purity or higher is provided.
More Like This:
| JPH02167 | 5-THIA-DELTA7-PROSTAGLANDIN E AND PRODUCTION THEREOF |
| WO/2001/017957 | PROSTAGLANDIN E ANALOGUES |
Inventors:
GREENWOOD ALAN KENNETH
MCHATTIE DEREK
THOMPSON DAVID GEORGE
CLISSOLD DEREK WYNDHAM
MCHATTIE DEREK
THOMPSON DAVID GEORGE
CLISSOLD DEREK WYNDHAM
Application Number:
JP2009278234A
Publication Date:
March 11, 2010
Filing Date:
December 08, 2009
Export Citation:
Assignee:
RESOLUTION CHEMICALS LTD
International Classes:
C07C405/00; C07B53/00; C07D307/93; C07B61/00; C07D307/935; C07F7/18; C07F9/38; C08F295/00; C25B3/23; C07B57/00
Domestic Patent References:
| JPH10182465A | 1998-07-07 | |||
| JPH07165703A | 1995-06-27 | |||
| JPH03501025A | 1991-03-07 | |||
| JPH06500804A | 1994-01-27 | |||
| JPS6137752A | 1986-02-22 |
Other References:
BAHRAM RESUL ET AL.: "Phenyl-substituted prostaglandins: potent and selective antiglaucoma agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 36, JPN7012002226, 1993, pages 243 - 248, XP000673914, ISSN: 0002248428, DOI: 10.1021/jm00054a008
Attorney, Agent or Firm:
Hiromichi Nanjo
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