To provide an industrially suitable method more efficiently producing a purine nucleoside compound useful as a synthetic intermediate for medicines.
The method for producing a purine nucleoside compound comprises reacting D-xylose (II) with a compound (III) in the presence of an acid, subjecting the reaction product to acid hydrolysis to give a compound (IV), selectively protecting the OH group at the 5-position to give a compound (V), oxidizing the OH group at the 3-position to give a compound (VI), reducing the C=O at the 3-position to give a compound (VII), reacting the compound with a compound (VIII) to give a compound (IX), subjecting the compound to an acid hydrolyzed reaction to give a compound (X), acylating the compound to give a compound (I), reacting the compound with a compound (XI) in a nitrile-based solvent or an ester-based solvent in the presence of a silylating agent and a Lewis acid and deacylating the 2' position to give a compound (XII).
KAWAKAMI TAKEHIKO
IWANAGA YOSHIHIKO
LI GE
MA RUJIAN
XU JIYOU
ZHU WEI
