Title:
テクネチウム-99mジエチレントリアミン五酢酸ジエステルの製造方法
Document Type and Number:
Japanese Patent JP3566536
Kind Code:
B2
Abstract:
The present invention relates a technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit for the diagnosis of renal disorders. Accordingly, the present invention provides a technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit for the diagnosis of renal disorders wherein technetium-99m diethylene triamine pentaacetic acid dimethyl ester has Rf value = zero in silica gel / acetone TLC system and Rf value = 1 in silica gel / acetonitrile water (1:1) TLC system and technecium-99m diethylene triamine pentaacetic acid dimethyl ester movement is of the order of half of the distance as compared to the standard compound (technecium-99m diethylene triamine pentaacetic acid) on conducting paper electrophoresis. The process for the preparation of a technetium-99m radiolabelled diethylene triamine pentaacetic acid diester kit for the diagnosis of renal disorders comprises: (a) Adding appropriate amount of stannous ion to a dilute aqueous solution of diethylene triamine pentaacetic diester prepared by known methods (b) Keeping the resultant solution abtained in step (a) in an evacuated rubber sealed injection vial flushed with nitrogen; (c) lyophilising the said kit and storing the lyophilised product an obtained in step (b) at 4 DEG C; (d) radiolabelling the said lyophilised product with Tc-99m by allowing the kit to attain the room temparature before addition of 99m TcO4; (e) shaking the kit vigorously to obtain the radiolabelled product available for use within a period of an hour.
Inventors:
Mita Chatter Jae
Calabi Sen
Som Nasu Bannerje
Calabi Sen
Som Nasu Bannerje
Application Number:
JP7812698A
Publication Date:
September 15, 2004
Filing Date:
March 25, 1998
Export Citation:
Assignee:
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH
International Classes:
A61K51/00; A61K51/04; C07F13/00; (IPC1-7): A61K51/00
Domestic Patent References:
| JP62501288A |
Foreign References:
| EP0089143A1 |
Other References:
Chemical Reviews,1993年,93(3),1137-1156
Journal of Pharmaceutical Sciences,1979年,68(2),194-196
Journal of Pharmaceutical Sciences,1979年,68(2),194-196
Attorney, Agent or Firm:
Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane