Title:
蛍光タンパク質に特異的なＴ細胞受容体を有する遺伝子導入動物の作製方法
Document Type and Number:
Japanese Patent JP6876434
Kind Code:
B2
Abstract:
This invention relates to a transgenic non-human mammal whose genome comprises a polynucleotide sequence encoding a T cell receptor that is specific to a fluorescent protein, where the T cell of the non-human mammal comprises the T cell receptor. The present invention also relates to an isolated T cell from the transgenic non-human mammal of the present invention , an isolated T cell comprising an expression construct comprising a polynucleotide sequence that encodes a T cell receptor that is specific to a fluorescent protein, methods of making transgenic non-human mammals comprising T cell receptors that are specific to a fluorescent protein, a method of depleting cells in a non-human mammal using isolated T cells that encode a T cell receptor that is specific to a target protein, and a method of characterizing a T cell response to an agent.
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Inventors:
Agde Judith
Brown brian
Brown brian
Application Number:
JP2016542829A
Publication Date:
May 26, 2021
Filing Date:
September 12, 2014
Export Citation:
Assignee:
Icahn School of Medicine at Mount Sinai
International Classes:
A01K67/027; C12N5/10; C12N15/09; C12Q1/04
Other References:
Gene Ther、2000.発行、Vol.7, No.23、p.2036-2040
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto