Title:
METHOD FOR PRODUCTION OF 1,5-DIDEOXY-1,5-IMINO HEXITOL FROM OXIME OR IMINE
Document Type and Number:
Japanese Patent JP2008001711
Kind Code:
A
Abstract:
To provide a method for preparation of 1,5-dideoxy-1,5-imino hexitols of hexose sugars from new hydroxy group-protected oxime intermediates.
The method includes the processes of (a) reacting an acid ester or a hydrazide of a 5-hexulosonic acid oxime or alkylimine with hydrogen and a hydrogenation catalyst in an acidic solvent to form a 5-imino-5-deoxyaldonic acid lactam and (b) reducing the lactam with a reducing agent to form the 1,5-dideoxy-1,5-imino hexitol. The hexitols are useful as drugs.
Inventors:
HOLLINGSWORTH RAWLE I
PISTIA-BRUEGGEMAN GABRIELA
PISTIA-BRUEGGEMAN GABRIELA
Application Number:
JP2007200331A
Publication Date:
January 10, 2008
Filing Date:
August 01, 2007
Export Citation:
Assignee:
UNIV MICHIGAN
International Classes:
C07D211/46; B01J23/42; C07D211/76; C07H7/027; C07B61/00
Domestic Patent References:
| JPS55105667A | 1980-08-13 | |||
| JPS55105666A | 1980-08-13 | |||
| JPH06505638A | 1994-06-30 |
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio
Hajime Asamura
Yukihiro Ikeda
Naganuma Akio