Title:
METHOD FOR PRODUCTION OF FINELY DISPERSED TABLET COMPOSITION CONSISTING OF MICROCAPSULE CONTAINING SPRAYED AND DRIED SODIUM DICHLOFENAC AND HAVING ENTERIC COATING
Document Type and Number:
Japanese Patent JPH04230625
Kind Code:
A
Abstract:
PURPOSE: To provide a method for producing an enteric tablet dispersing microcapsules of diclofenac sodium with enteric coating. CONSTITUTION: This method for producing an enteric tablet comprises (a) a step for dissolving diclofenac sodium in a suitable amount of water, (b) a step for forming a suspension by adding an effective amount of vehicle to the obtained solution, (c) a step for forming a slurry by adding Eudargit L 30D and PEG 6000 as an enteric coating material to the obtained slurry, (d) a step for atomizing and spray-drying the obtained slurry to provide powder, (e) a step for mixing the spray-dried powder with a mixture of neocel and flostarch and (f) a step for forming the obtained powder mixture into a tablet to provide the objective enteric tablet. A microcapsule having enteric coating is produced by using an aqueous latex polymer dispersion such as Eudragit L 30D as an enteric coating polymer.
Inventors:
RII JIEN CHIEN
CHIYUN NAN CHIEN
SHIYAN YAN RIN
CHIYUN NAN CHIEN
SHIYAN YAN RIN
Application Number:
JP41859990A
Publication Date:
August 19, 1992
Filing Date:
December 27, 1990
Export Citation:
Assignee:
SUTANDAADO CHEM ANDO PHARM COR
International Classes:
A61K9/22; A61K9/16; A61K9/20; A61K9/26; A61K9/52; A61K9/58; A61K9/62; A61K31/19; A61K31/195; A61K47/38; A61P29/00; (IPC1-7): A61K9/22; A61K9/26; A61K9/52; A61K9/58; A61K9/62; A61K31/19; A61K47/38
Domestic Patent References:
| JPS6259207A | 1987-03-14 | |||
| JPS6144811A | 1986-03-04 | |||
| JPH01502589A | 1989-09-07 |
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)