Title:
１−（４−アミノ−２−メチルベンゾイル）−７−クロロ−５−オキソ−２，３，４，５−テトラヒドロ−１Ｈ−１−ベンザゼピンの精製方法
Document Type and Number:
Japanese Patent JP6917226
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method for purifying 1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine, which is one of the producing intermediates of tolvaptan.SOLUTION: This invention relates to a purification method, comprising the steps of: (a) making a rough 1-(4-amino-2-methylbenzoyl)-7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine react with sulfonic acid, to conduct isolation as a sulfonate; (b) recrystallizing the sulfonate obtained at the step (a) from an organic solvent; and (c) making the sulfonate obtained at the step (b) react with a base to conduct desalination, thereby conducting isolation as a free object.SELECTED DRAWING: None
Inventors:
Han, Shin
John, Sung Hyun
Lee Shinyoung
John, Sung Hyun
Lee Shinyoung
Application Number:
JP2017136251A
Publication Date:
August 11, 2021
Filing Date:
July 12, 2017
Export Citation:
Assignee:
Hexa Pharma Tech Company Limited
International Classes:
C07D223/16
Foreign References:
| CN102060769A | ||||
| CN103373960A |
Attorney, Agent or Firm:
Ryu Iwatani