Title:
METHOD AND REAGENT FOR MEASURING LUPUS ANTICOAGULANT SUBSTANCE ANTIBODY
Document Type and Number:
Japanese Patent JP3461871
Kind Code:
B2
Abstract:
PURPOSE: To measure an lupus anticoagulant substance(LA) antibody causing thrombus specifically and quantitatively by adding a predetermined quantity of activated protein C into a blood-, a plasma-, and a tissue sample and, after holding them thermostatically, measuring the residual quantity of physiological substrate of the protein C in the sample or the activity of protein S.
CONSTITUTION: In order to measure the LA-antibody in a blood-, a plasma-, and a tissue sample by suppressing the neutralization of activated protein C on a coagulation system with an LA-antibody, a predetermined quantity of activated protein C is added to the sample and, after holding the sample thermostatically, the residual quantity of physiological substrate of the protein C in the sample or the activity of protein S is measured. The quantity of existing LA-antibody is the compared with a standard containing no LA-antibody. The suppression rate of the activity of activated protein C in a group of patient where the LA-antibody is detected has no correlation with the measure concentration of LA-antibody but has a good correlation with the sporadic emergency of thrombus.
Inventors:
Gerd Muller-Berghaus
Bernd Petsch
Christoph Zerich
Bernd Petsch
Christoph Zerich
Application Number:
JP22319893A
Publication Date:
October 27, 2003
Filing Date:
September 08, 1993
Export Citation:
Assignee:
Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
International Classes:
C07K16/36; G01N33/86; G01N33/53; G01N33/92; G01N33/96; (IPC1-7): G01N33/53; C07K16/36
Domestic Patent References:
| JP5180835A |
Other References:
【文献】米国特許505135(US,A)
Attorney, Agent or Firm:
Toshio Yano (2 outside)