Title:
METHOD FOR REMOVING ALLYL GROUP OR ALLYLOXYCARBONYL GROUP
Document Type and Number:
Japanese Patent JP3044175
Kind Code:
B2
Abstract:
PURPOSE: To remove an allyl group, etc., in high selectivity and high yield without exercising bad influence on other functional group by reacting a specific compound containing an allyl group, etc., with a sulfinic acid compound in the presence of a Pd catalyst in an inert solvent.
CONSTITUTION: This method for removing an allyl group or allyloxycarbonyl group is to react an ally ester of a carboxylic acid, an allyloxycarbonyl derivative of an alcohol or an allyloxycarbonyl derivative of an amine with a sulfinic acid compound of the formula, X-SO3M [X is a 1-20C (substituted)alkyl or (substituted)phenyl, etc.; M is H, an alkali metal or an ammonium salt residue] in the presence of Pd catalyst comprising tetrakis(triphenylphosphine)palladium (O), etc., capable of readily forming π-allyl complex by reaction with the allyl compound in an inert solvent such as alcohols, etc. and convert these derivative into a carboxylic acid, an alcohol or an amine.
Inventors:
Masanori Honda
Hiromasa Morita
Isao Nagakura
Hiromasa Morita
Isao Nagakura
Application Number:
JP2893195A
Publication Date:
May 22, 2000
Filing Date:
January 26, 1995
Export Citation:
Assignee:
Pfizer Pharmaceuticals Co., Ltd.
International Classes:
C07D499/897; B01J31/02; B01J31/24; C07B51/00; C07B61/00; C07D499/04; C07D499/86; C07D499/87; C07D499/88; C07D501/04; C07D501/20; C07H9/04; (IPC1-7): C07B51/00; B01J31/02; B01J31/24; C07D499/04; C07D499/86; C07D499/87; C07D499/897; C07D501/04; C07H9/04
Domestic Patent References:
| JP6220054A | ||||
| JP5594321A | ||||
| JP61286331A | ||||
| JP3130293A | ||||
| JP441489A | ||||
| JP8508986A |
Other References:
ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ（１９８７），２８（３８），ｐａｇｅｓ４３７１−４３７２
ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ（１９９３），３４（２６），ｐａｇｅｓ４１８９−４１９２
ＴＥＴＲＡＨＥＤＲＯＮ ＬＥＴＴＥＲＳ（１９９３），３４（２６），ｐａｇｅｓ４１８９−４１９２
Attorney, Agent or Firm:
Hiroshi Kobayashi