To find out a pathway for controlling the expression of NEDL1 and to provide a method for screening a compound inhibiting the onset or progress of FALS (familial amyotrophic lateral sclerosis) by utilizing the same.
This method for screening includes the following processes: a process of culturing cells under conditions of the presence and absence of a tested compound; a process of measuring the amount of expression of HIF-1α (hypoxia inducible factor-1α) in each of the cultured cells; and a process of judging that the tested compound is the compound inhibiting the onset or progress of the familial amyotrophic lateral sclerosis when the amount of expression of the HIF-1α in the cells cultured in the presence of the tested compound is smaller than that in the cells cultured in the absence of the tested compound.
| WO/2005/013893 | CANCER RELATED GENES |
| WO/2006/133215 | GLMS RIBOZYME COENZYMES AND METHODS OF USE THEREOF |
| JP5661071 | RNA detection method |
TAKENAGA KEIZO
MOCHIZUKI SHIGENOBU
CHIBA PREFECTURE
| JP2003135063A | 2003-05-13 |
| WO2005056822A1 | 2005-06-23 |
Shiro Terasaki
Kimoto
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