Title:
METHOD FOR SELECTIVELY DESULFATING AND OXIDIZING SULFATED SACCHARIDE
Document Type and Number:
Japanese Patent JP3217112
Kind Code:
B2
Abstract:
PURPOSE: To obtain a new sulfated saccharide useful as a raw material for an improver for lipid metabolism by reacting an organic base salt of sulfated saccharide with N,O-bis(trimethylsilyl)acetamide and selectively desulfating a sulfate group bonded to primary hydroxyl group.
CONSTITUTION: An aqueous solution of a sulfated saccharide (e.g. methyl-α- galactopyranoside-6 ammonium sulfate) is treated with an anion exchange resin and substituted into a free sulfuric ester type and the anion exchange resin is removed. The solution is mixed with an organic base such as pyridine to prepare an organic base salt of sulfated saccharide (e.g. methyl-α- galactosylpyranoside-6 pyridinium sulfate salt). An N,O-bis(trimethylsilyl) acetamide is added in the presence of the organic base salt, reacted at 80°C for about one hour and sulfate group bonded to primary hydroxyl group of the sulfated saccharide is selectively desulfated to give a sulfated saccharide containing a sulfuric ester at a specific position which has not been known.
Inventors:
Saburo Hara
Application Number:
JP7320192A
Publication Date:
October 09, 2001
Filing Date:
February 25, 1992
Export Citation:
Assignee:
Seikagaku Corporation
International Classes:
C07H1/00; C07H11/00; C07H15/04; (IPC1-7): C07H1/00; C07H11/00
Domestic Patent References:
| JP5178876A |
Attorney, Agent or Firm:
Hajime Tsukuni (1 person outside)
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