Title:
METHOD FOR SYNTHESIZING HOMOALLYL TYPE AMINE AND CHIRAL ZIRCONIUM CATALYST
Document Type and Number:
Japanese Patent JP3563347
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a new technical means by which a homoallyl type amine can be synthesized from an imine compound in a high yield in a good diastereomer selectivity and in a good enathiomer selectivity.
SOLUTION: This method for synthesizing the homoallyl type amine represented by the general formula (3) (R1 is an aromatic hydrocarbon group or a heterocyclic group which may have one or more substituents; R2 is an aliphatic hydrocarbon group or an aliphatic hydrocarbon group having one or more hydroxyl groups or one or more protected hydroxyl groups; R3 is H or an aliphatic hydrocarbon group) comprises reacting an imine compound represented by formula (1) with an allyl stannane compound represented by formula (2) in the presence of a chiral zirconium catalyst comprising a (R)-3,3'- dihalogeno-1,1'-bi-2-naphthol and a zirconium alkoxide.
Inventors:
Osamu Kobayashi
Haruro Ishitani
Haruro Ishitani
Application Number:
JP2000404902A
Publication Date:
September 08, 2004
Filing Date:
December 29, 2000
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C07D317/58; B01J31/02; C07B53/00; C07B61/00; C07C213/02; C07C215/76; C07C217/84; C07D307/52; (IPC1-7): C07C213/02; C07C215/76; C07C217/84; C07D307/52; C07D317/58
Domestic Patent References:
| JP3432476B2 |
Other References:
J. Am. Chem. Soc., Vol.122, No.22 (June 7, 2000) p.5403-p.5404
Chemistry Letters, No.11 (1998) p.1131-p.1132
Chemical Abstracts, 要約番号135:152586
Chemistry Letters, No.11 (1998) p.1131-p.1132
Chemical Abstracts, 要約番号135:152586
Attorney, Agent or Firm:
Toshio Nishizawa