PURPOSE: To obtain new conduritol B useful as a glycosidase inhibitor for treating obesity, adiposis, hyperlipemia, diabetes, prediabetes, etc.
CONSTITUTION: D-Conduritol B expressed by formula I. The aforementioned compound is obtained by deprotecting and converting a protecting group R1 bound to O atoms at the 1- and 2-positions of 1D1,2-O-(R1)-3,4,5,6-tetra-O-(R2)- myoinositol expressed by formula II (R1 and R2 are protecting group) into hydroxyl groups, then dehydroxylating the resultant compound and subsequently removing protecting groups (R2) bound to the 1- to 4-positions in the obtained 1D-1,2,3,4-tetra-O-(R2)-cyclohex-5-ene-(1,3/2,4)-tetrol. Furthermore, a compound synthesized by carrying out inversion of hydroxyl group at the 1-position of L-quebrachitol, demethylation of methoxy group at the 2-position and protection of hydroxyl groups in no particular order is preferably used as the compound expressed by formula II.
KAGEYAMA KUNIO
MACHIDA MORIHISA
OZAKI SHOICHIRO
AKIYAMA TAKAHIKO
