Title:
エクスビボで制御性T細胞の作成を加速するための方法および組成物
Document Type and Number:
Japanese Patent JP2011519271
Kind Code:
A
Abstract:
The present invention is directed to generating regulatory T cells by treating a cell culture that includes non-regulatory T cells with a regulatory composition. The invention encompasses methods utilizing a regulatory composition that includes agents that prevent methylation of the locus for the FOXP3 transcription factor, agents that accelerate differentiation of T cells into suppressor cells, and agents that are histone deacetylase inhibitors. The invention also encompasses compositions of regulatory T cells generated by culturing non-regulatory T cells with a regulatory composition as well as the use of such regulatory T cells in the treatment of autoimmune diseases and aberrant immune responses.
Inventors:
David A. Howitz
Dixon Jay Gray
Dixon Jay Gray
Application Number:
JP2011504202A
Publication Date:
July 07, 2011
Filing Date:
April 10, 2009
Export Citation:
Assignee:
University of Southern California
International Classes:
C12N5/0783; A61K35/12; A61K38/00; A61K39/395; A61K45/00; A61P37/06
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa
Fumio Inai
Manami Sawamoto
Hiroshi Yamazaki
Kenji Tomita
Mina Shiga
Masayuki Nakagawa
Fumio Inai
Manami Sawamoto
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