Title:
F18イー・コリ関連疾患に対して遺伝学的に耐性のブタを同定する方法および組成物
Document Type and Number:
Japanese Patent JP3637420
Kind Code:
B2
Abstract:
The present invention provides non-invasive methods and compositions to differentiate, with a high level of sensitivity and specificity, swine that are genetically susceptible to diseases associated with F18 E. coli infection, from resistant swine. DNA polymorphisms in the swine alpha (1,2) fucosyltransferase 1 (FUT1) gene were used to differentiate resistant from susceptible swine. The invention includes a polypeptide with amino acid substitutions, encoded by the nucleotide polymorphisms, a molecular diagnostic assay, and a kit for the differentiation, of E. coli F18-adhesion resistant, heterozygous (carrier) and homozygous susceptible pigs. The molecular test identifies susceptibility to oedema disease and postweaning diarrhea with high sensitivity and specificity, therefore, is useful to swine breeder in their effort to enhance for resistance. Information on the polymorphisms of the present invention provides insight into causation and treatment of E. coli associated intestinal disorders.
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Inventors:
Brad Tee, Bosworth
Forgery, Peter
Forgery, Peter
Application Number:
JP55057998A
Publication Date:
April 13, 2005
Filing Date:
May 20, 1998
Export Citation:
Assignee:
Biotechnology Research and Development Corporation
United States of America, As Represented By The Secretary Of Agriculture
Swiss Federal Institute of Technology Zurich
United States of America, As Represented By The Secretary Of Agriculture
Swiss Federal Institute of Technology Zurich
International Classes:
A01K67/027; A61K38/45; A61P1/00; A61P31/04; C07H21/04; C07K14/47; C12N5/10; C12N9/10; C12Q1/02; C12Q1/68; C12Q1/6876; C12N15/09; G01N33/50; C12R1/91; (IPC1-7): C12N15/09; A01K67/027; A61K38/45; A61P1/00; A61P31/04; C12N9/10; C12Q1/02; C12Q1/68; G01N33/50
Attorney, Agent or Firm:
Hidesaku Yamamoto