Title:
細菌の付着およびストレス耐性を修飾する方法および組成物
Document Type and Number:
Japanese Patent JP2008537885
Kind Code:
A
Abstract:
Methods and compositions are provided which improve the adhesion of a bacteria to target substrates and/or improve the stress tolerance of a bacteria. Methods comprise exposing bacteria to adhesion adaptive conditions and thereby increasing the adhesion activity and/or stress tolerance of the bacteria. Further provided are bacteria having a modulated production of autoinducer-2. Compositions include recombinant bacteria expressing nucleic acid molecules involved in the pathway of autoinducer-2 production. Further provided are autoinducer-2-related fusion proteins, antigenic peptides, antibodies, and vectors. Methods of screening compounds or environmental conditions which will stimulate the production of autoinducer-2 and/or produce an adhesion adaptive response are further provided, as are various methods of use for the bacteria having increased adhesion and/or stress tolerance.
Inventors:
Back, bee logan
Ascarate-Peril, Andrea
Clan Hammer, Todd Earl
Eric Alterman
Ascarate-Peril, Andrea
Clan Hammer, Todd Earl
Eric Alterman
Application Number:
JP2008506757A
Publication Date:
October 02, 2008
Filing Date:
April 14, 2006
Export Citation:
Assignee:
North Carolina State University
International Classes:
C12N1/20; A61K35/74; A61K38/00; A61K48/00; C12N1/21; C12N15/09; C12P9/00; C12Q1/02
Domestic Patent References:
| JP99064023A | ||||
| JPS62500722A | 1987-03-26 | |||
| JP2001158743A | 2001-06-12 | |||
| JP2004101249A | 2004-04-02 | |||
| JP2003522731A | 2003-07-29 |
Foreign References:
| WO2003026687A1 | 2003-04-03 |
Other References:
JPN6011049990; 第７８回日本細菌学会総会 , 200502, ｐ．１１２， Ｐ１-２００／ＷＳ１３-１１
JPN6011049991; 日本畜産学会第９８回大会講演要旨集 , 2001, ｐ．４７， Ｓ６-３-３
JPN6011049992; Ｍｏｌ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．４１， Ｎｏ．２, 2001, ｐ．４６３-４７６
JPN6011049993; Ｉｎｆｅｃｔ． Ｉｍｍｕｎ． Ｖｏｌ．６８， Ｎｏ．６, 2000, ｐ．３１９３-３１９９
JPN6011049995; Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．１４９， Ｎｏ．８, 2003, ｐ．１９５３-１９５６
JPN6011049997; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８４， Ｎｏ．１３, 2002, ｐ．３４５０-３４５６
JPN6011049999; ＢＭＣ Ｅｖｏｌｕｔ． Ｂｉｏｌ． Ｖｏｌ．４， Ｎｏ．３６, 2004, ｐ．１-１１
JPN6012040996; Ｊ． Ｇｅｒｍｇｒｅｅ ｌｉｆｅ ｇｎｏｔｏｂｉｏｌ． Ｖｏｌ．３５， Ｎｏ．１, 200509, ｐ．５２-５５
JPN6012040999; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８５， Ｎｏ．１, 2003, ｐ．２７４-２８４
JPN6012041002; Ｎａｔ． Ｒｅｖ． Ｖｏｌ．３, 200505, ｐ．３８３-３９６
JPN6012041005; Ａｐｐｌ． Ｅｎｖｉｒｏｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．７１， Ｎｏ．１０, 200510, ｐ．５７９４-５８０４
JPN6012041016; Ｂｕｃｋ， Ｂｒｏｃｋ Ｌｏｇａｎ: 'Ｆｕｎｃｔｉｏｎａｌ Ａｎａｌｙｓｉｓ ｏｆ Ａｄｈｅｓｉｏｎ Ｆａｃｔｏｒｓ ａｎｄ Ｓｉｇｎａｌｉｎｇ Ｍｅｃｈａｎｉｓｍｓ ｉｎ Ｌａｃｔｏｂａｃｉｌｌｕｓ ａｃｉｄｏｐｈｉｌｕｓ ＮＣＦＭ' Ｔｈｅｓｅｓ , 2006
JPN6012041018; 日本細菌学雑誌 Ｖｏｌ．５８， Ｎｏ．１, 2003, ｐ．３３４， ２Ｐ-１３-８
JPN6011049989; Ａｐｐｌ． Ｅｎｖｉｒｏｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．６０， Ｎｏ．１２, 1994, ｐ．４４８７-４４９４
JPN6012040994; Ｉｎｆｅｃｔ． Ｉｍｍｕｎ． Ｖｏｌ．７１， Ｎｏ．４, 2003, ｐ．１９７２-１９７９
JPN6011049991; 日本畜産学会第９８回大会講演要旨集 , 2001, ｐ．４７， Ｓ６-３-３
JPN6011049992; Ｍｏｌ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．４１， Ｎｏ．２, 2001, ｐ．４６３-４７６
JPN6011049993; Ｉｎｆｅｃｔ． Ｉｍｍｕｎ． Ｖｏｌ．６８， Ｎｏ．６, 2000, ｐ．３１９３-３１９９
JPN6011049995; Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．１４９， Ｎｏ．８, 2003, ｐ．１９５３-１９５６
JPN6011049997; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８４， Ｎｏ．１３, 2002, ｐ．３４５０-３４５６
JPN6011049999; ＢＭＣ Ｅｖｏｌｕｔ． Ｂｉｏｌ． Ｖｏｌ．４， Ｎｏ．３６, 2004, ｐ．１-１１
JPN6012040996; Ｊ． Ｇｅｒｍｇｒｅｅ ｌｉｆｅ ｇｎｏｔｏｂｉｏｌ． Ｖｏｌ．３５， Ｎｏ．１, 200509, ｐ．５２-５５
JPN6012040999; Ｊ． Ｂａｃｔｅｒｉｏｌ． Ｖｏｌ．１８５， Ｎｏ．１, 2003, ｐ．２７４-２８４
JPN6012041002; Ｎａｔ． Ｒｅｖ． Ｖｏｌ．３, 200505, ｐ．３８３-３９６
JPN6012041005; Ａｐｐｌ． Ｅｎｖｉｒｏｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．７１， Ｎｏ．１０, 200510, ｐ．５７９４-５８０４
JPN6012041016; Ｂｕｃｋ， Ｂｒｏｃｋ Ｌｏｇａｎ: 'Ｆｕｎｃｔｉｏｎａｌ Ａｎａｌｙｓｉｓ ｏｆ Ａｄｈｅｓｉｏｎ Ｆａｃｔｏｒｓ ａｎｄ Ｓｉｇｎａｌｉｎｇ Ｍｅｃｈａｎｉｓｍｓ ｉｎ Ｌａｃｔｏｂａｃｉｌｌｕｓ ａｃｉｄｏｐｈｉｌｕｓ ＮＣＦＭ' Ｔｈｅｓｅｓ , 2006
JPN6012041018; 日本細菌学雑誌 Ｖｏｌ．５８， Ｎｏ．１, 2003, ｐ．３３４， ２Ｐ-１３-８
JPN6011049989; Ａｐｐｌ． Ｅｎｖｉｒｏｎ． Ｍｉｃｒｏｂｉｏｌ． Ｖｏｌ．６０， Ｎｏ．１２, 1994, ｐ．４４８７-４４９４
JPN6012040994; Ｉｎｆｅｃｔ． Ｉｍｍｕｎ． Ｖｏｌ．７１， Ｎｏ．４, 2003, ｐ．１９７２-１９７９
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto
Arihara Koichi
Matsushima Tetsuo
Hidefumi Kawamura
Naomi Yoshida
Ayako Nakamura
Masayuki Okamoto
Fukagawa Eri
Satoshi Morimoto