Title:
角膜内皮および関連細胞のバイオポリマー上での増殖のための方法および組成物ならびに人工角膜移植片の作成
Document Type and Number:
Japanese Patent JP2007509643
Kind Code:
A
Abstract:
This invention discloses methods to attach and grow a monolayer of cultured human corneal endothelial cells onto the endothelial side of the stroma synthesized from biopolymer to generate a more bio-equivalent artificial cornea. The approaches will include the use of attachment and growth promoting agents such as fibronectin, laminin, RGDS, collagen type IV, bFGF conjugated with polycarbophil, and EGF conjugated with polycarbophil. The patent also describes a method to create a self-sustaining polymer containing adhesive molecules and growth factors to support the attachment and proliferation of cultured human corneal endothelial cells for corneal transplantation either as a half-thickness device or full-thickness button replacement. An approach for the implantation of cultured retinal pigment epithelial (RPE) cells into the sub-retinal space for treatment of age-related macular degeneration (ARMD) is disclosed in this invention. This method will enable the delivery of the transplanted RPE in a sheet of monolayer cells and will be better suited to perform their physiological function.
Inventors:
Ge Ming LUI
Application Number:
JP2006534293A
Publication Date:
April 19, 2007
Filing Date:
October 07, 2004
Export Citation:
Assignee:
Ge Ming LUI
CELLULAR BIOENGINEERING, INC.
CELLULAR BIOENGINEERING, INC.
International Classes:
A61L27/00; A61F2/14; A61K35/44; A61K38/00; A61K38/17; A61K38/22; A61L27/30; A61L27/34; A61L27/38; A61L27/44; A61P27/02; A61P41/00; A61P43/00; C12N5/071; C12N5/10; A61K35/12; C12M3/00
Domestic Patent References:
| JP2002281964A | 2002-10-02 | |||
| JPH01249048A | 1989-10-04 | |||
| JP2003522806A | 2003-07-29 | |||
| JPH08325160A | 1996-12-10 | |||
| JPH01249048A | 1989-10-04 | |||
| JP2003522806A | 2003-07-29 | |||
| JP2002078723A | 2002-03-19 | |||
| JP2002281964A | 2002-10-02 |
Foreign References:
| US20020007217A1 | 2002-01-17 | |||
| WO1994027630A1 | 1994-12-08 | |||
| US20020007217A1 | 2002-01-17 |
Other References:
JPN5006016535; ＫＬＥＥ， ＤＯＲＩＳ: ＡＤＶＡＮＣＥＳ ＩＮ ＰＯＬＹＭＥＲ ＳＣＩＥＮＣＥ Ｖ１４９, 1999, Ｐ１-５７
JPN5006016537; ＥＮＧＥＬＭＡＮＮ Ｋ: ＤＥＲ ＯＰＨＴＨＡＬＭＯＬＯＧＥ Ｖ９６ Ｎ９, 199909, Ｐ５５５-５６２, ＳＰＲＩＮＧＥＲ
JPN5006016535; ＫＬＥＥ， ＤＯＲＩＳ: ＡＤＶＡＮＣＥＳ ＩＮ ＰＯＬＹＭＥＲ ＳＣＩＥＮＣＥ Ｖ１４９, 1999, Ｐ１-５７
JPN5006016537; ＥＮＧＥＬＭＡＮＮ Ｋ: ＤＥＲ ＯＰＨＴＨＡＬＭＯＬＯＧＥ Ｖ９６ Ｎ９, 199909, Ｐ５５５-５６２, ＳＰＲＩＮＧＥＲ
JPN6009013757; 日本眼科学会雑誌：Ｖｏｌ．１０６ Ｎｏ．１２ Ｐａｇｅ．８０５-８３６ （２００２．１２．１０）
JPN6012025926; Ｉｎｖｅｓｔ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｉｓ． Ｓｃｉ． Ｖｏｌ．４５， Ｎｏ．９, 2004, ２９９２-２９９７
JPN5006016537; ＥＮＧＥＬＭＡＮＮ Ｋ: ＤＥＲ ＯＰＨＴＨＡＬＭＯＬＯＧＥ Ｖ９６ Ｎ９, 199909, Ｐ５５５-５６２, ＳＰＲＩＮＧＥＲ
JPN5006016535; ＫＬＥＥ， ＤＯＲＩＳ: ＡＤＶＡＮＣＥＳ ＩＮ ＰＯＬＹＭＥＲ ＳＣＩＥＮＣＥ Ｖ１４９, 1999, Ｐ１-５７
JPN5006016537; ＥＮＧＥＬＭＡＮＮ Ｋ: ＤＥＲ ＯＰＨＴＨＡＬＭＯＬＯＧＥ Ｖ９６ Ｎ９, 199909, Ｐ５５５-５６２, ＳＰＲＩＮＧＥＲ
JPN6009013757; 日本眼科学会雑誌：Ｖｏｌ．１０６ Ｎｏ．１２ Ｐａｇｅ．８０５-８３６ （２００２．１２．１０）
JPN6012025926; Ｉｎｖｅｓｔ． Ｏｐｈｔｈａｌｍｏｌ． Ｖｉｓ． Ｓｃｉ． Ｖｏｌ．４５， Ｎｏ．９, 2004, ２９９２-２９９７
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Michiko Matsutani
Mina Shiga
Sakurai Yoko