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Title:
標的-受容体との結合を促進および強化する方法、およびそのための装置
Document Type and Number:
Japanese Patent JP2004536694
Kind Code:
A
Abstract:
The present invention relates to a device for the simultaneous conduction of a multiplicity of binding reactions on a substrate with a first surface, said surface comprising discrete and isolated locations of one such binding reaction, said binding reaction being generated upon contact between the substrate and a fluidic sample comprising one or more target molecules capable of binding with at least one receptor molecule at least partly tethered to said first surface of the substrate, and further comprising means for enhancing the diffusion fluidic flow of the sample over the substrate, whereby said means for enhancing the diffusion fluidic flow comprises shear-force field generating means, whereby said means comprise a second surface positioned in a flow interacting manner in said flow channel, said second surface is able to be moved in a substantial parallel mode over the first surface. The invention further relates to a method for binding one or more target molecules comprised within a fluid sample to at least one receptor molecule at least partly tethered to a first surface in a flow channel, wherein said target molecules are transported parallel to said first surface by means of shear-force field generating means, wherein the shear-force field generating means comprises a second surface, which second surface is moved in a substantially parallel mode past or over said first surface.

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Inventors:
Desmet, Hert
Baron, Gino
Application Number:
JP2002585095A
Publication Date:
December 09, 2004
Filing Date:
April 11, 2002
Export Citation:
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Assignee:
VRIJE UNIVERSIEIT BRUSSEL
International Classes:
G01N37/00; B01F5/06; B01F11/00; B01F13/00; B01F15/00; B01J19/00; B01L3/00; C12M1/00; C12M1/34; C12N15/09; C12Q1/68; G01N30/92; G01N30/32; G01N30/38; G01N30/60; G01N35/00; (IPC1-7): B01J19/00; C12M1/00; C12M1/34; G01N37/00
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda



 
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