コレステロールオゾン化産物の作用の相殺によるアテローム性動脈硬化症の治療および予防のために有用な治療薬を同定する方法

Japanese Patent JP2009504184

A

As illustrated herein, cholesterol is oxidized when it is present in atherosclerotic plaques. This reaction generates cholesterol oxidation or ozonation products that can act as chemotactic attractants of macrophages, can promote differentiation of monocytes into macrophages and can increase expression of E-selectin and Class A scavenger receptor (SR-A). The present application is directed to methods of using such cholesterol ozonoation products to identify agents that can be used to treat atherosclerosis and other inflammatory artery diseases.

WO/2021/201116	METHOD FOR SCREENING COMPOUND HAVING LYSOSOME-DAMAGE-REPAIRING ACTIVITY
WO/2002/004509	GENE EXPRESSION, GENOME ALTERATION AND REPORTER EXPRESSION IN MYOFIBROBLASTS AND MYOFIBROBLAST-LIKE CELLS
WO/2017/082616	NOVEL KINASE FOR TREATING AND PREVENTING FUNGAL INFECTIONS, AND USE THEREOF

Wentworth, Paul

JP2008527030A

February 05, 2009

August 14, 2006

Click for automatic bibliography generation  

The Scripts Research Institution

C12Q1/02; A61K45/00; A61P3/06; A61P9/10; C07J41/00; C07J61/00; G01N33/15; G01N33/50

Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura

Previous Patent: JP2009504183

Next Patent: ＧＤＦ−８に対するアンタゴニスト抗体ならびにＡＬＳおよびその他のＧ�...