METHODS FOR INCREASING EFFICACY OF FOLR1 CANCER THERAPY

Japanese Patent JP2022062219

A

To provide methods for improving the success of cancer therapies that target the human folate receptor 1.SOLUTION: The invention provides kits comprising reagent useful in the methods. The present invention provides a method for identifying a subject predisposed to respond favorably to a Folate Receptor 1 (FOLR1)-targeting anti-cancer therapeutic, the method comprising detecting FOLR1 expression in a tissue sample from the subject. The present invention also provides a method for increasing the likelihood of effectiveness of a cancer treatment, the method comprising administering a therapeutically effective dose of a FOLR1-targeting anti-cancer therapeutic to a subject, wherein FOLR1 expression in a tissue sample from the subject has been found to be increased.SELECTED DRAWING: None

JP2005120099	NEW METHOD FOR DIAGNOSING, MONITORING, STAGING, IMAGING AND TREATING VARIOUS CANCERS
WO/2003/066877	COMPOSITIONS AND METHODS RELATING TO HEPATIC SPECIFIC GENES AND PROTEINS
WO/2014/193999	BIOMARKER METHODS AND COMPOSITIONS

CHRISTINA N CARRIGAN
KATHLEEN R WHITEMAN
GILLIAN PAYNE
SHARRON LADD

JP2022019315A

April 19, 2022

February 10, 2022

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IMMUNOGEN INC

G01N33/574; A61K31/337; A61K31/366; A61K31/407; A61K31/437; A61K31/5386; A61K31/5513; A61K31/5517; A61K31/704; A61K38/07; A61K39/395; A61K47/68; A61P11/00; A61P15/00; A61P35/00; G01N33/53; G01N33/536

Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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