複数のカラムを組み合わせたクロマトグラフィーを用いて化学品および医薬品を調製する方法

Japanese Patent JP5122667

B2

In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In a process to extract a chiral pharmaceutical agent, isomer or biomolecule from a mixture, the product is separated from the mixture by simulated moving bed technology contra-flow chromatography. In the process the prior art 5-pump arrangement is replaced by a 4-pump arrangement. The process employs a single eluent constant flow feed pump and a single eluent compensation vessel and no circulation pump. The assembly employs no more than four pumps in the chromatography circuit. The prior art discharge pump, extract or refined discharge is replaced by a regulator valve. The automatic discharge of impure eluent in the circuit is facilitated by on-line detection and a regulator valve. Measurements made of the recyclate flow and the associated redundancy is increased by data comparison, increasing precision of the volumetric flow control. Independent claims are included for: (1) a modular valve system with a master plate, a valve housing, and a control unit housing, where the control system is located within an interior pneumatic chamber; and (2) a commensurate production process.

Jochen Struve
Karsten-Ullrich Kratt
Gerhard Nate
Jern Greifenberg
Sebastian becker
Heinz Kancy
Peter Yane
Berthold Justin

JP2011097192A

January 16, 2013

April 25, 2011

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Bayer Technology Services GmbH

B01D15/08; G01N30/46; B01D15/18; F16B11/00; F16D1/068; F16D3/38; F16K1/00; G01N30/42

JP3172688A
JP8229306A
JP54156223A
JP11153231A
JP56153164A

WO2003052308A1

Samejima Mutsumi
Kyousei Tamura
Haruhiko Ema

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