Title:
METHODS, COMPOSITIONS AND COMPONENTS FOR CRISPR-CAS9 EDITING OF TGFBR2 IN T CELLS FOR IMMUNOTHERAPY
Document Type and Number:
Japanese Patent JP2023179469
Kind Code:
A
Abstract:
To provide CRISPR/CAS-related genome editing systems, to provide compositions and methods for targeting a transforming growth factor β receptor II (TGFBR2) locus, as well as to provide cells edited using these systems, compositions and methods.SOLUTION: Provided is a genome editing system comprising gRNA comprising a targeting domain that is complementary with a target sequence of a TGFBR2, and an RNA-guided nuclease.SELECTED DRAWING: None
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Inventors:
STEPHEN MICHAEL BURLEIGH
MELISSA CHIN
FRED HARBINSKI
CHRISTOPHER HEATH NYE
BLYTHE D SATHER
QUEENIE VONG
GORDON GRANT WELSTEAD
CHRIS WILSON
MELISSA CHIN
FRED HARBINSKI
CHRISTOPHER HEATH NYE
BLYTHE D SATHER
QUEENIE VONG
GORDON GRANT WELSTEAD
CHRIS WILSON
Application Number:
JP2023146660A
Publication Date:
December 19, 2023
Filing Date:
September 11, 2023
Export Citation:
Assignee:
EDITAS MEDICINE INC
JUNO THERAPEUTICS INC
JUNO THERAPEUTICS INC
International Classes:
C12N15/09; A61K35/17; A61P35/00; A61P35/02; C12N5/0783; C12N5/10; C12N9/16; C12N15/113; C12N15/55; C12N15/63; C12N15/864; C12N15/867; G01N33/53
Attorney, Agent or Firm:
Hatsushi Shimizu
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
Hideki Kodera
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Masato Ozeki
Kazuya Kawamoto
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