Title:
脈管アクセスを改善するための方法および組成物
Document Type and Number:
Japanese Patent JP5632580
Kind Code:
B2
Abstract:
Disclosed is an implantable material comprising a biocompatible matrix and cells which, when provided to a vascular access structure, can promote functionality generally. For example, implantable material of the present invention can enhance maturation of an arteriovenous native fistula as well as prolong the fistula in a mature, functional state suitable for dialysis. Additionally, the present invention can promote formation of a functional arteriovenous graft suitable for dialysis as well as promote formation of a functional peripheral bypass graft. Implantable material can be configured as a flexible planar form or a flowable composition with shape-retaining properties suitable for implantation at, adjacent or in the vicinity of an anastomoses or arteriovenous graft. According to the methods disclosed herein, the implantable material is provided to an exterior surface of a blood vessel. Certain embodiments of the flexible planar form define a slot. The materials and methods of the present invention comprise cells, preferably endothelial cells or cells having an endothelial-like phenotype.
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Inventors:
ニュージェント， ヘレン マリー
エーデルマン， エレザ
ダラル， アヌパン
ボリンジャー， スティーブ
エパリー， スコット
エーデルマン， エレザ
ダラル， アヌパン
ボリンジャー， スティーブ
エパリー， スコット
Application Number:
JP2008518189A
Publication Date:
November 26, 2014
Filing Date:
June 05, 2006
Export Citation:
Assignee:
シャイア リジェネラティブ メディシン， インコーポレイテッド
International Classes:
C12N5/071; A61F2/06; A61L27/00; C12N5/07
Attorney, Agent or Firm:
Shusaku Yamamoto
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa