Title:
腫瘍の増殖の阻害および免疫応答の増強のための方法および組成物
Document Type and Number:
Japanese Patent JP2004537500
Kind Code:
A
Abstract:
Provided is a method and composition for enhancing an immune response in a subject by administering to the subject an inhibitor of IL-13 or an inhibitor of an NK-T cell to the subject. The method can be used to prevent growth of a tumor in the subject, e.g., to inhibit tumor recurrence or metastasis. The method can also be used to enhance a response to a vaccine in a subject.
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Inventors:
Bazowski, Jay A.
Terrabe, Masaki
Donaldson, Debrady.
Matsui, Saw
Noven-Truth, Nancy
Paul, William E.
Terrabe, Masaki
Donaldson, Debrady.
Matsui, Saw
Noven-Truth, Nancy
Paul, William E.
Application Number:
JP2002555834A
Publication Date:
December 16, 2004
Filing Date:
October 22, 2001
Export Citation:
Assignee:
Genetics Institute, LRC
The Government of the United States as Represented by the Secretary of the Department of Health and Human Services
The Government of the United States as Represented by the Secretary of the Department of Health and Human Services
International Classes:
A61K47/34; A61K38/00; A61K38/17; A61K39/00; A61K39/39; A61K39/395; A61K45/00; A61K48/00; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/04; C07K14/54; C07K16/24; C07K16/28; (IPC1-7): A61K45/00; A61K38/00; A61K39/00; A61K39/395; A61K47/34; A61K48/00; A61P31/12; A61P31/14; A61P31/18; A61P31/20; A61P35/00; A61P35/02; A61P37/04
Other References:
JPN6008016323, ＲＵＴＨ， Ｊ．Ｈ．， ｅｔ ａｌ．, "ＩＮＴＥＲＬＥＵＫＩＮ ４ ＡＮＤ １３ ＰＡＲＴＩＣＩＰＡＴＩＯＮ ＩＮ ＭＹＣＯＢＡＣＴＥＲＩＡＬ （ｔｙｐｅ−１） ＡＮＤ ＳＣＨＩＳＴＯＳＯＭＡＬ （ｔｙｐｅ−２） ＡＮＴＩＧＥＮ−ＥＬＩＣＩ", ＣＹＴＯＫＩＮＥ, 200005, Ｖｏｌ．１２， Ｎｏ．５, ｐ．４３２−４４４
JPN6008016326, ＣＨＩＡＲＡＭＯＮＴＥ， Ｍ．Ｇ．， ｅｔ ａｌ．, "Ａｎ ＩＬ−１３ ｉｎｈｉｂｉｔｏｒ ｂｌｏｃｋｓ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｈｅｐａｔｉｃ ｆｉｂｒｏｓｉｓ ｄｕｒｉｎｇ ａ Ｔ−ｈｅｌｐｅｒ ｔｙｐｅ ２−ｄｏｍｉｎａｔｅｄ ｉｎｆ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ, 199909, Ｖｏｌ．４０１， Ｎｏ．６, ｐ．７７７−７８５
JPN6008016324, ＳＥＲＶＥ， Ｈ．， ｅｔ ａｌ．, "Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｐｒｏｌｉｆｅｒａｔｉｏｎ ａｎｄ Ｃｌｏｎａｌ Ｇｒｏｗｔｈ ｏｆ Ｈｕｍａｎ Ｂｒｅｓｔ Ｃａｎｃｅｒ Ｃｅｌｌｓ ｂｙ Ｉｎｔｅｒｌｅｕｋｉｎ １３", ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 19960801, Ｖｏｌ．５６， Ｎｏ．１５, ｐ．３５８３−３５８８
JPN7008003165, ＬＥＢＥＬ−ＢＩＮＡＹ， Ｓ．， ｅｔ ａｌ．, "Ｅｘｐｅｒｉｍｅｎｔａｌ ｇｅｎｅ ｔｈｅｒａｐｙ ｏｆ ｃａｎｃｅｒ ｕｓｉｎｇ ｔｕｍｏｒ ｃｅｌｌｓ ｅｎｇｅｎｅｅｒｅｄ ｔｏ ｓｅｃｒｅｔｅ ｉｎｔｅｒｌｅｕｋｉｎ−１３", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＬＯＧＹ, 199508, Ｖｏｌ．２５， Ｎｏ．８, ｐ．２３４０−２３４８
JPN6008016325, ＢＡＩＬＥＲ， Ｒ．Ｔ．， ｅｔ ａｌ．, "ＩＬ−１３ ａｎｄ ＴＮＦ−α ｉｎｈｉｂｉｔ ｄｕａｌ−ｔｒｏｐｉｃ ＨＩＶ−１ ｉｎ ｐｒｉｍａｒｙ ｍａｃｒｏｐｈａｇｅｓ ｂｙ ｒｅｄｕｃｔｉｏｎ ｏｆ ｓｕｒｆａｃｅ ｅｘｐｒｅｓｓｉｏｎ", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＬＯＧＹ, 200005, Ｖｏｌ．３０， Ｎｏ．５, ｐ．１３４０−１３４９
JPN6008016327, ＬＯＰＥＺ， Ｍ．， ｅｔ ａｌ．, "ＩＬ−１３ ｉｎｄｕｃｅｓ ＣＤ３４＋ ｃｅｌｌｓ ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｇ−ＣＳＦ ｍｏｂｉｌｉｚｅｄ ｂｌｏｏｄ ｔｏ ｄｉｆｆｅｒｅｎｔｉａｔｅ ｉｎ ｖｉｔｒｏ ｉｎｔｏ ｐｏｔｅｎｔ", Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｉｃａｌ Ｍｅｔｈｏｄｓ, 19971027, Ｖｏｌ．２０８， Ｎｏ．２, ｐ．１１７−１２９
JPN6008016326, ＣＨＩＡＲＡＭＯＮＴＥ， Ｍ．Ｇ．， ｅｔ ａｌ．, "Ａｎ ＩＬ−１３ ｉｎｈｉｂｉｔｏｒ ｂｌｏｃｋｓ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｈｅｐａｔｉｃ ｆｉｂｒｏｓｉｓ ｄｕｒｉｎｇ ａ Ｔ−ｈｅｌｐｅｒ ｔｙｐｅ ２−ｄｏｍｉｎａｔｅｄ ｉｎｆ", Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｉｎｖｅｓｔｉｇａｔｉｏｎ, 199909, Ｖｏｌ．４０１， Ｎｏ．６, ｐ．７７７−７８５
JPN6008016324, ＳＥＲＶＥ， Ｈ．， ｅｔ ａｌ．, "Ｉｎｈｉｂｉｔｉｏｎ ｏｆ Ｐｒｏｌｉｆｅｒａｔｉｏｎ ａｎｄ Ｃｌｏｎａｌ Ｇｒｏｗｔｈ ｏｆ Ｈｕｍａｎ Ｂｒｅｓｔ Ｃａｎｃｅｒ Ｃｅｌｌｓ ｂｙ Ｉｎｔｅｒｌｅｕｋｉｎ １３", ＣＡＮＣＥＲ ＲＥＳＥＡＲＣＨ, 19960801, Ｖｏｌ．５６， Ｎｏ．１５, ｐ．３５８３−３５８８
JPN7008003165, ＬＥＢＥＬ−ＢＩＮＡＹ， Ｓ．， ｅｔ ａｌ．, "Ｅｘｐｅｒｉｍｅｎｔａｌ ｇｅｎｅ ｔｈｅｒａｐｙ ｏｆ ｃａｎｃｅｒ ｕｓｉｎｇ ｔｕｍｏｒ ｃｅｌｌｓ ｅｎｇｅｎｅｅｒｅｄ ｔｏ ｓｅｃｒｅｔｅ ｉｎｔｅｒｌｅｕｋｉｎ−１３", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＬＯＧＹ, 199508, Ｖｏｌ．２５， Ｎｏ．８, ｐ．２３４０−２３４８
JPN6008016325, ＢＡＩＬＥＲ， Ｒ．Ｔ．， ｅｔ ａｌ．, "ＩＬ−１３ ａｎｄ ＴＮＦ−α ｉｎｈｉｂｉｔ ｄｕａｌ−ｔｒｏｐｉｃ ＨＩＶ−１ ｉｎ ｐｒｉｍａｒｙ ｍａｃｒｏｐｈａｇｅｓ ｂｙ ｒｅｄｕｃｔｉｏｎ ｏｆ ｓｕｒｆａｃｅ ｅｘｐｒｅｓｓｉｏｎ", ＥＵＲＯＰＥＡＮ ＪＯＵＲＮＡＬ ＯＦ ＩＭＭＵＮＯＬＯＧＹ, 200005, Ｖｏｌ．３０， Ｎｏ．５, ｐ．１３４０−１３４９
JPN6008016327, ＬＯＰＥＺ， Ｍ．， ｅｔ ａｌ．, "ＩＬ−１３ ｉｎｄｕｃｅｓ ＣＤ３４＋ ｃｅｌｌｓ ｉｓｏｌａｔｅｄ ｆｒｏｍ Ｇ−ＣＳＦ ｍｏｂｉｌｉｚｅｄ ｂｌｏｏｄ ｔｏ ｄｉｆｆｅｒｅｎｔｉａｔｅ ｉｎ ｖｉｔｒｏ ｉｎｔｏ ｐｏｔｅｎｔ", Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｉｃａｌ Ｍｅｔｈｏｄｓ, 19971027, Ｖｏｌ．２０８， Ｎｏ．２, ｐ．１１７−１２９
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita