Title:
固形腫瘍を予防および治療するための方法および組成物
Document Type and Number:
Japanese Patent JP5075927
Kind Code:
B2
Abstract:
Compositions and methods of preventing or treating a breast cancer are disclosed. The composition and method can utilize an endothelin B agonist and a chemotherapeutic agent as active ingredients to treat a solid tumor in mammals, including humans. Alternatively, the composition and method can utilize an endothelin B antagonist and an optional angiogenesis inhibitor to treat a solid tumor in mammals, including humans.
Inventors:
Grati, anil
Application Number:
JP2010020534A
Publication Date:
November 21, 2012
Filing Date:
February 01, 2010
Export Citation:
Assignee:
The Board of Trustees of the University of Illinois
International Classes:
A61K38/00; A61K31/00; A61K31/28; A61K31/282; A61K31/337; A61K31/4745; A61K31/519; A61K31/704; A61K33/243; A61K38/17; A61K38/20; A61K38/21; A61K38/22; A61K45/00; A61K45/06; A61P35/00; A61P43/00
Other References:
BELL, K.M., et al.,MODIFICATION OF BLOOD FLOW IN THE HSN TUMOUR AND NORMAL TISSUES OF THE RAT BY THE ENDOTHELIN ETB RECEPTOR AGONIST, IRL 1620,Int. J. Cancer,1999年 1月18日,Vol.80, No.2,p.295-302
BELL, K.M., et al.,Effect of Endothelin-1 and Sarafotoxin S6c on Blood Flow in a Rat Tumor,Journal of Cardiovascular Pharmacology,1995年,Vol.26, No.Suppl.3,p.S222-S225
DEL BUFALO, D., et al.,Endothelin-1 acts as a survival factor in ovarian carcinoma cells,Clinical Science,2002年 8月,Vol.103, No. Suppl.48,p.302S-305S
石橋みゆき, 他.,肝細胞癌の増殖とエンドセリン,成長科学協会研究年報,1996年 7月,No.19,p.193-204
LAHAV, R., et al.,An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo,Proc. Natl. Acad. Sci. USA,1999年 9月28日,Vol.96, No.20,p.11496-11500
NELSON, J.B., et al.,Endothelin-1 Production and Decreased Endothelin B Receptor Expression in Advanced Prostate Cancer,CANCER RESEARCH,1996年 2月15日,Vol.56, No.4,p.663-668
BELL, K.M., et al.,Effect of Endothelin-1 and Sarafotoxin S6c on Blood Flow in a Rat Tumor,Journal of Cardiovascular Pharmacology,1995年,Vol.26, No.Suppl.3,p.S222-S225
DEL BUFALO, D., et al.,Endothelin-1 acts as a survival factor in ovarian carcinoma cells,Clinical Science,2002年 8月,Vol.103, No. Suppl.48,p.302S-305S
石橋みゆき, 他.,肝細胞癌の増殖とエンドセリン,成長科学協会研究年報,1996年 7月,No.19,p.193-204
LAHAV, R., et al.,An endothelin receptor B antagonist inhibits growth and induces cell death in human melanoma cells in vitro and in vivo,Proc. Natl. Acad. Sci. USA,1999年 9月28日,Vol.96, No.20,p.11496-11500
NELSON, J.B., et al.,Endothelin-1 Production and Decreased Endothelin B Receptor Expression in Advanced Prostate Cancer,CANCER RESEARCH,1996年 2月15日,Vol.56, No.4,p.663-668
Attorney, Agent or Firm:
Yoshihiro Tsunoda
Yasu Furukawa
Toshio Nishitani
Keiji width
Yasu Furukawa
Toshio Nishitani
Keiji width