Title:
1419、58765および2210を用いて心血管疾患を処置するための方法および組成物
Document Type and Number:
Japanese Patent JP2005512528
Kind Code:
A
Abstract:
The present invention relates to methods for the diagnosis and treatment of cardiovascular disease, including, but not limited to, atherosclerosis, reperfusion injury, hypertension, restenosis, arterial inflammation, thrombosis and endothelial cell disorders. Specifically, the present invention identifies the differential expression of 1419, 58765 or 2210 genes in cardiovascular disease states, relative to their expression in normal, or non-cardiovascular disease states, and/or in response to manipulations relevant to cardiovascular disease. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating cardiovascular disease. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cardiovascular disease.
Inventors:
Logan, Thomas Joseph
Chun, Myung
Chun, Myung
Application Number:
JP2003551507A
Publication Date:
May 12, 2005
Filing Date:
December 10, 2002
Export Citation:
Assignee:
MILLENNIUM PHARMACEUTICALS, INC.
International Classes:
G01N33/50; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P3/06; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; C12N15/09; C12Q1/02; C12Q1/68; G01N33/15; G01N33/68; (IPC1-7): C12Q1/02; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P3/06; A61P7/02; A61P9/00; A61P9/04; A61P9/06; A61P9/10; A61P9/12; C12N15/09; G01N33/15; G01N33/50
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita