Title:
カプサイシンを使用した疼痛の治療のための方法及び組成物
Document Type and Number:
Japanese Patent JP7282736
Kind Code:
B2
Abstract:
The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.
Inventors:
James N Campbell
Peter Di Hanson
Gary F. Musso
Dreisen Ostvic
Randall Stevens
Peter Di Hanson
Gary F. Musso
Dreisen Ostvic
Randall Stevens
Application Number:
JP2020502343A
Publication Date:
May 29, 2023
Filing Date:
July 20, 2018
Export Citation:
Assignee:
Centlexion Therapeutics Corporation
International Classes:
A61K31/165; A61K9/08; A61K31/167; A61K45/00; A61K47/02; A61M5/14; A61M35/00; A61P19/02; A61P23/02; A61P25/04; A61P29/02; A61P43/00
Domestic Patent References:
| JP2015536998A | ||||
| JP2016540830A |
Other References:
Journal of Neurophysiology,1991年, 66(1),pp.190-211
Attorney, Agent or Firm:
Norito Yamao
Yasushi Ochiai
Yasushi Ochiai
Previous Patent: Powder formulations, cartridges and devices
Next Patent: COAXIAL OUTPUT JOINT METHOD FOR MAGNETRON
Next Patent: COAXIAL OUTPUT JOINT METHOD FOR MAGNETRON