Title:
過酸化亜硝酸の過剰発現によって起きる哺乳動物の疾患および傷害の治療のための方法および組成物
Document Type and Number:
Japanese Patent JP5634011
Kind Code:
B2
Abstract:
The present invention provides a method for treating wounds and diseases in mammals, caused by mammalian cells involved in an inflammatory response, by altering indigenous in vivo levels of peroxynitrous acid, and salts thereof. The method comprises contacting the mammalian cells with a therapeutically effective amount of a reactive oxygen species mediator, wherein the reactive oxygen species mediator is selected from the group consisting of pyruvates, pyruvate precursors, α-keto acids having four or more carbon atoms, precursors of α-keto acids having four or more carbon atoms, and the salts thereof, wherein mediation of reactive oxygen species results in mediation of peroxynitrous acid. The present invention further provides a pharmaceutical composition for treating wounds and diseases in mammals, caused by mammalian cells involved in an inflammatory response, by altering indigenous in vivo levels of peroxynitrous acid, and salts thereof.
Inventors:
マーティン，アラン
Application Number:
JP2007555250A
Publication Date:
December 03, 2014
Filing Date:
February 10, 2006
Export Citation:
Assignee:
ノース セル ファーマシューティカル インコーポレイテッドＮＯＲＴＨ ＣＥＬＬ ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ，ＩＮＣ．
International Classes:
A61K31/19; A61K31/194; A61K31/195; A61K31/28; A61K45/00; A61K45/06; A61P17/00; A61P17/02; A61P17/16; A61P17/18; A61P29/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P39/06; A61P43/00
Attorney, Agent or Firm:
Haruo Hamada
West entrance 克
Teiji Akatsu
Tanabe 稜
West entrance 克
Teiji Akatsu
Tanabe 稜
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