Title:
1,3-プロパンジスルホン酸を送達するための方法、化合物、および組成物
Document Type and Number:
Japanese Patent JP2013501733
Kind Code:
A
Abstract:
The invention relates to methods, compounds, and compositions for delivering 1,3-propanedisulfonic acid (1,3PDS) in a subject, preferably a human subject. The invention encompasses compounds that will yield or generate 1,3PDS, either in vitro or in vivo. The invention also relates to sulfonate ester prodrugs of 1,3PDS as well as Gemini dimmers and oligomers of 1,3PDS for the prevention or treatment of associated diseases and conditions.
Inventors:
Kong, Schenchy
Ravens, Nigel
Abdel Raheem, Bourjid
Sibra, Stefan
Frenet, Richard
Joan, Renaud
Ravens, Nigel
Abdel Raheem, Bourjid
Sibra, Stefan
Frenet, Richard
Joan, Renaud
Application Number:
JP2012524066A
Publication Date:
January 17, 2013
Filing Date:
August 06, 2010
Export Citation:
Assignee:
BHI Limited Partnership
International Classes:
C07C309/65; A61K31/10; A61K31/132; A61K31/222; A61K31/235; A61K31/27; A61K31/343; A61K31/357; A61K31/365; A61K31/39; A61K31/4155; A61K31/4178; A61K31/444; A61P3/04; A61P3/06; A61P3/10; A61P13/12; C07C303/30; C07C313/02; C07D213/64; C07D231/12; C07D233/60; C07D307/00; C07D307/33; C07D319/06; C07D327/00; C07F9/09; C07F9/40; C07B61/00
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JPN6014035367; Ｂｕｌｌ． Ｃｈｅｍ． Ｓｏｃ． Ｊｐｎ Ｖｏｌ．５６ Ｎｏ．４, 1983, ｐｐ．１２５７-１２５８
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JPN7014002509; Ｌｉｃｈｔｅｎｂｅｒｇｅｒ Ｊ． ｅｔ ａｌ: Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ , 1961, ｐｐ．３６３-３７１
JPN6014035367; Ｂｕｌｌ． Ｃｈｅｍ． Ｓｏｃ． Ｊｐｎ Ｖｏｌ．５６ Ｎｏ．４, 1983, ｐｐ．１２５７-１２５８
JPN7014002507; Ｅｓａｙａｎ ｅｔ ａｌ．: Ｉｚｕ． Ａｋａｄ． Ｎａｕｋ Ａｒｍ． ＳＳＲ， Ｋｈｉｍ． Ｎａｕｋｉ ｖｏｌ． １８ ｎｏ．３ ｐｐ．３０９-３１２ , 1965
JPN7014002508; Ｏｇａｎｅｓｙａｎ Ｅ． Ｅ． ｅｔ ａｌ: Ａｒｍ． Ｋｈｉｍ． Ｚｈ． １９７５， ｖｏｌ． ２８ ｎｏ．８ ｐｐ．６６９-７１ , 1976
JPN7014002509; Ｌｉｃｈｔｅｎｂｅｒｇｅｒ Ｊ． ｅｔ ａｌ: Ｂｕｌｌｅｔｉｎ ｄｅ ｌａ Ｓｏｃｉｅｔｅ Ｃｈｉｍｉｑｕｅ ｄｅ Ｆｒａｎｃｅ , 1961, ｐｐ．３６３-３７１
Attorney, Agent or Firm:
Ryoichi Takaoka