Title:
薬剤の少なくとも１つのトリスルフィド結合を含むタンパク質中のチオール部分へのコンジュゲーション方法
Document Type and Number:
Japanese Patent JP7219256
Kind Code:
B2
Abstract:
The invention provides improved methods of conjugating an agent to a thiol moiety in a protein that contains at least one disulfide bond and at least one trisulfide bond. Exemplary embodiments include the production of antibody drug conjugates substantially free of impurities created in the presence of reactive sulfide moieties in the production processes.
Inventors:
Franklin Jamie
Lin Shin Shin
Gorrell Jeffrey
Tully Timothy
Hutchinson Matthew
Bechtel Charity Tucker
Lin Shin Shin
Gorrell Jeffrey
Tully Timothy
Hutchinson Matthew
Bechtel Charity Tucker
Application Number:
JP2020199681A
Publication Date:
February 07, 2023
Filing Date:
December 01, 2020
Export Citation:
Assignee:
Genentech, Incorporated
International Classes:
C07K1/113; A61K31/09; A61K31/337; A61K31/36; A61K31/395; A61K31/407; A61K31/4178; A61K31/475; A61K31/537; A61K31/7076; A61K31/7088; A61K38/05; A61K38/06; A61K38/19; A61K39/395; A61K47/65; A61K47/68; A61K51/10; A61P31/04; A61P35/00; A61P37/02; A61P37/06; C07K16/00
Domestic Patent References:
| JP6956630B2 | ||||
| JP2004530651A | ||||
| JP2003500053A | ||||
| JP2014042522A | ||||
| JP6025012A | ||||
| JP2076899A | ||||
| JP2010509192A | ||||
| JP11124395A |
Foreign References:
| US20130295007 | ||||
| WO2011041721A1 |
Other References:
Katherine Cumnock, et al.,Trisulfide Modification Impacts the Reduction Step in Antibody-Drug Conjugation Process.,Bioconjugate Chem.,2013年,24,1154-1160
Attorney, Agent or Firm:
Saegusa International Patent Office