Title:
選択された粒子、特に生物細胞を磁気的に分離するための方法と装置
Document Type and Number:
Japanese Patent JP4713735
Kind Code:
B2
Abstract:
A method and apparatus for magnetically separating target particles of a selected type from a sample in order to produce a concentration of the target particles in the sample, or a depletion of the sample with respect to the target particles, by producing a sample mixture of the sample with magnetic particles having a selective affinity to magnetically stain the target particles; producing a flow of a buffer liquid through a tube which includes an inlet connectable to a source of buffer liquid, and an outlet for the buffer liquid; after a flow of the buffer liquid has been produced through the tube, introducing the sample mixture into the buffer liquid flowing through the tube such that the buffer liquid forms a continuous liquid carrier for the sample mixture as both are fed through the tube; and applying a magnetic field across the tube at a magnetizing station therein to cause the magnetically-stained target particles to be separated and retained in the buffer liquid within the tube at the magnetizing station.
Inventors:
Davidson, Chime
Klein, Offer
Ramish, Ahalon
Klein, Offer
Ramish, Ahalon
Application Number:
JP2000549351A
Publication Date:
June 29, 2011
Filing Date:
May 13, 1999
Export Citation:
Assignee:
Bio Sep Limited
International Classes:
B03C1/00; G01N33/543; A61K35/14; B01D43/00; B03C1/005; B03C1/035; B03C1/30; G01N33/553
Domestic Patent References:
| JP8510390A | ||||
| JP4500008A |
Foreign References:
| US4710472 | ||||
| US4904391 | ||||
| US5711871 |
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano